Inflammatory macrophage derived TNFα downregulates estrogen receptor α via FOXO3a inactivation in human breast cancer cells.
Animals
Breast Neoplasms
/ genetics
Cells, Cultured
Down-Regulation
Estrogen Receptor alpha
/ genetics
Female
Forkhead Box Protein O3
/ metabolism
Humans
MCF-7 Cells
Macrophages
/ cytology
Mammary Neoplasms, Experimental
/ genetics
Mice
Monocyte-Macrophage Precursor Cells
/ cytology
Tumor Necrosis Factor-alpha
/ metabolism
Breast cancer
Endocrine resistance
Estrogen receptor
FOXO3a
Macrophage
TNFalpha
Journal
Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226
Informations de publication
Date de publication:
01 05 2020
01 05 2020
Historique:
received:
04
12
2019
revised:
24
02
2020
accepted:
27
02
2020
pubmed:
8
3
2020
medline:
15
12
2020
entrez:
8
3
2020
Statut:
ppublish
Résumé
Patients with estrogen receptor α positive (ERα
Identifiants
pubmed: 32145253
pii: S0014-4827(20)30137-3
doi: 10.1016/j.yexcr.2020.111932
pii:
doi:
Substances chimiques
Estrogen Receptor alpha
0
FOXO3 protein, human
0
Forkhead Box Protein O3
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111932Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest KL is a board member of Cantargia AB, a company developing IL1RAP inhibitors. This does not alter the Author's adherence to all guidelines for publication. The authors otherwise declare no competing interest.