Retinal layer abnormalities and their association with clinical and brain measures in psychotic disorders: A preliminary study.
Bipolar disorder
Cognition
Magnetic resonance imaging (MRI)
Optical coherence tomography (OCT)
Schizophrenia
Journal
Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001
Informations de publication
Date de publication:
30 05 2020
30 05 2020
Historique:
received:
08
10
2019
revised:
24
02
2020
accepted:
27
02
2020
pubmed:
8
3
2020
medline:
21
10
2020
entrez:
8
3
2020
Statut:
ppublish
Résumé
Studies utilizing optical coherence tomography (OCT) in psychosis have identified abnormalities in retinal cytoarchitecture. We aim to analyze retinal layer topography in psychosis and its correlation with clinical and imaging parameters. Macular retinal images were obtained via OCT in psychosis probands (n = 25) and healthy controls (HC, n = 15). Clinical, cognitive and structural MRI data were collected from participants. No thinning was noted for the retinal nerve fiber, ganglion cell or inner plexiform layers. We found significant thinning in the right inner temporal, right central, and left inner superior quadrants of the outer nuclear layer (ONL) in probands compared to HC. Thickening of the outer plexiform layer (OPL) was observed in the right inner temporal, left inner superior, and left inner temporal quadrants. The right inner temporal and left inner superior quadrants of both the OPL and ONL showed significant inverse correlations. Retinal pigment epithelium thinning correlated with worse mania symptoms, and thinning in the ONL was associated with worse cognitive function. ONL thinning was also associated with smaller total brain and white matter volume. Our findings suggest that outer retinal layers may provide additional insights into the pathophysiology of psychosis, possibly reflecting synaptic or inflammatory aberrations that lead to retinal pathologies.
Identifiants
pubmed: 32145500
pii: S0925-4927(20)30033-0
doi: 10.1016/j.pscychresns.2020.111061
pmc: PMC7183910
mid: NIHMS1574876
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111061Subventions
Organisme : NIMHD NIH HHS
ID : L32 MD014380
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH078113
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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