Ultrasound-Guided Focused Ultrasound Treatment for Painful Bone Metastases: A Pilot Study.
Bone metastases
High-intensity focused ultrasound
Tolerability
Journal
Ultrasound in medicine & biology
ISSN: 1879-291X
Titre abrégé: Ultrasound Med Biol
Pays: England
ID NLM: 0410553
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
19
04
2019
revised:
20
01
2020
accepted:
29
01
2020
pubmed:
9
3
2020
medline:
17
8
2021
entrez:
9
3
2020
Statut:
ppublish
Résumé
Focused ultrasound (FUS) for palliation of bone metastases has typically been performed under magnetic resonance guidance. To address limitations of this approach, this pilot study evaluated a stand-alone, portable FUS device guided by diagnostic ultrasound alone (ultrasound [US]-guided FUS). Nine patients were treated; safety and efficacy were assessed for 10 d after the procedure, and medical charts were evaluated to assess durability of pain response. The procedure was safe and tolerable, with four patients reporting minor skin-related irritations. Average pain score decreased from 6.9 at baseline to 3.2 at day 10; analgesic use on average also decreased from baseline to day 10. Six patients had durable pain relief as assessed after the follow-up period. Our study provides evidence that US-guided FUS is a safe, tolerable and versatile procedure. It appears to be effective in achieving durable pain response in patients with painful bone metastases. Further research is required to refine the technology and optimize its efficacy.
Identifiants
pubmed: 32146008
pii: S0301-5629(20)30058-2
doi: 10.1016/j.ultrasmedbio.2020.01.032
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1455-1463Informations de copyright
Copyright © 2020 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest disclosure The authors declare no conflicts of interest.