[Modelling the bronchial epithelium in chronic obstructive pulmonary disease using human induced pluripotential stem cells].
Modélisation de l’épithélium bronchique dans la bronchopneumopathie chronique obstructive par les cellules souches pluripotentes induites humaines.
Bronchial epithelium
Bronchopneumopathie chronique obstructive
Cellule souche pluripotente induite humaine
Chronic obstructive pulmonary disease
Différenciation dirigée
Directed differentiation
Human induced pluripotential stem cells
Épithélium bronchique
Journal
Revue des maladies respiratoires
ISSN: 1776-2588
Titre abrégé: Rev Mal Respir
Pays: France
ID NLM: 8408032
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
12
01
2020
accepted:
12
01
2020
pubmed:
9
3
2020
medline:
21
10
2020
entrez:
9
3
2020
Statut:
ppublish
Résumé
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease leading to irreversible destruction of the terminal bronchioles. Although the precise patho-physiological mechanisms remain to be elucidated, the bronchial epithelium seems to play a pivotal role in the disease. Recent studies have highlighted a great heterogeneity among COPD patients, with various disease courses including, in about half the cases, an origin in childhood. Modelling of COPD is a major goal but currently available models are imperfect. Our work aims to create a new in vitro cellular model to study the pathology of the disease. The differentiation of human induced pluripotential stem cells (hiPSCs) in bronchial epithelium is a step towards a better understanding of the developmental origin and the identification of new therapeutic targets.
Identifiants
pubmed: 32146059
pii: S0761-8425(20)30034-6
doi: 10.1016/j.rmr.2020.02.003
pii:
doi:
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
197-200Informations de copyright
Copyright © 2020 SPLF. Published by Elsevier Masson SAS. All rights reserved.