Bioactive prenylated coumarins as potential anti-inflammatory and anti-HIV agents from Clausena lenis.
Anti-HIV activities
Anti-inflammatory effects
Clauselenins A and B
Clausena lenis
Prenylated coumarins
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
03
11
2019
revised:
21
01
2020
accepted:
24
02
2020
pubmed:
9
3
2020
medline:
2
3
2021
entrez:
9
3
2020
Statut:
ppublish
Résumé
The phytochemical study on the stems of Clausena lenis resulted in the isolation of three new prenylated coumarins, clauselenins A-C (1-3), together with nine known prenylated coumarins (4-12). The chemical structures of new prenylated coumarins (1-3) were elucidated by means of comprehensive spectral analyses and the known compounds (4-12) were determined by means of comparing their experimental spectral data with those described data in the literatures. All isolated prenylated coumarins were assessed for their anti-inflammatory effects together with anti-HIV activities in vitro. Prenylated coumarins 1-12 displayed remarkable inhibitory effects against nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with the IC
Identifiants
pubmed: 32146173
pii: S0045-2068(19)31870-X
doi: 10.1016/j.bioorg.2020.103699
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Anti-Inflammatory Agents
0
Coumarins
0
reverse transcriptase, Human immunodeficiency virus 1
EC 2.7.7.-
HIV Reverse Transcriptase
EC 2.7.7.49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103699Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.