Computational fluid dynamics simulation from microCT stacks of commercial biomaterials usable for bone grafting.
Bone graft
Computational fluid dynamics
Fluid flow
Microarchitecture
Permeation
microCT
Journal
Micron (Oxford, England : 1993)
ISSN: 1878-4291
Titre abrégé: Micron
Pays: England
ID NLM: 9312850
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
03
02
2020
revised:
27
02
2020
accepted:
28
02
2020
pubmed:
9
3
2020
medline:
6
11
2020
entrez:
9
3
2020
Statut:
ppublish
Résumé
Granules of calcium/phosphate biomaterials are used to fill small bone defects in oral and maxilla-facial surgery. Granules of natural (e.g., trabecular bone, coral) or synthetic biomaterials are provided by industry. Small granules can also form of putty. The 3D geometry of granules creates a macroporosity allowing invasion of vascular and bone cells when pores are larger than 300 μm. We analyzed the 3D-porosity of 11 different stacks of biomaterials: Osteopure®, CopiOs®, Bio-Oss®, TCP Dental HP®, KeraOs®, TCH®, Biocoral®, EthOss® and Nanostim®. For each granular biomaterial, two sizes of granules were analyzed: small and large. Microcomputed tomography (microCT) determined porosity and microarchitectural characteristics of the biomaterials stacks. Computational fluid dynamics (CFD), a simulation method, was used on the stacks of microCT images. Stacks of small granules had a much lower permeation and fluid velocity than large granules and the hydraulic tortuosity was increased. Significant correlations were observed between microarchitecture parameters (porosity, mean pore diameter and specific surface) and fluid dynamic parameters. The two putties were associated with low (or absence of) porosity and permeation study revealed a very low (or absence) of flow rate. Stacks of granules represent 3D scaffolds resembling trabecular bone with an interconnected porous microarchitecture. Small granules create pores less than 300 μm in diameter; this induces a low fluid flow rate. CFD simulates the accessibility of body fluids and progenitor cells and confirms that it is depending on the shape and 3D arrangements of granules within a stack. Large granules must be preferred to putties and small granules.
Identifiants
pubmed: 32146253
pii: S0968-4328(20)30037-8
doi: 10.1016/j.micron.2020.102861
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Calcium Phosphates
0
calcium phosphate
97Z1WI3NDX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102861Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest No conflicts of interest, financial or otherwise, are declared by the authors.