Caveolae: Formation, dynamics, and function.

Animals Caveolae / metabolism Humans Membrane Lipids / metabolism Membrane Proteins / metabolism Models, Biological Signal Transduction Stress, Physiological
Caveolae Caveolin Cavin EHD2 Lipid Membrane traffic

Journal

Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428

Informations de publication

Date de publication:
08 2020
Historique:
received: 19 11 2019
revised: 28 01 2020
accepted: 02 02 2020
pubmed: 9 3 2020
medline: 7 1 2021
entrez: 9 3 2020
Statut: ppublish

Résumé

Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a platform generated by caveolin integral membrane proteins and membrane lipids. This membranous assembly can bud off into the cell or can be disassembled releasing the cavin proteins into the cytosol. Disassembly can be triggered by increased membrane tension, or by stress stimuli, such as UV. Here, we discuss recent mechanistic studies showing how caveolae are formed and how their unique properties allow them to function as multifunctional protective and signaling structures.

Identifiants

DOI: 10.1016/j.ceb.2020.02.001 PMID: 32146331
pubmed: 32146331
pii: S0955-0674(20)30024-7
doi: 10.1016/j.ceb.2020.02.001
pii:
doi:

Substances chimiques

Membrane Lipids 0
Membrane Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

8-16

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

Auteurs

Robert G Parton (RG)

The University of Queensland, Institute for Molecular Bioscience, Brisbane, Queensland, 4072, Australia; The University of Queensland, Centre for Microscopy and Microanalysis, Brisbane, Queensland, 4072, Australia. Electronic address: R.Parton@imb.uq.edu.au.

Kerrie-Ann McMahon (KA)

The University of Queensland, Institute for Molecular Bioscience, Brisbane, Queensland, 4072, Australia. Electronic address: K.Mcmahon@imb.uq.edu.au.

Yeping Wu (Y)

The University of Queensland, Institute for Molecular Bioscience, Brisbane, Queensland, 4072, Australia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Caveolae: Formation, dynamics, and function.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Vésicules tapissées › Cavéoles › Caveolae: Formation, dynamics, and function.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Caveolae: Formation, dynamics, and function.
questionsmedicales.fr › Lipides › Lipides membranaires › Caveolae: Formation, dynamics, and function.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Caveolae: Formation, dynamics, and function.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Caveolae: Formation, dynamics, and function.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Caveolae: Formation, dynamics, and function.
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Caveolae: Formation, dynamics, and function.