A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing.
Biologics
Chemometrics
Downstream processing
Process analytical technology
Spectroscopy
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
25
10
2019
accepted:
10
01
2020
revised:
06
01
2020
pubmed:
9
3
2020
medline:
15
12
2020
entrez:
9
3
2020
Statut:
ppublish
Résumé
As competition in the biopharmaceutical market gets keener due to the market entry of biosimilars, process analytical technologies (PATs) play an important role for process automation and cost reduction. This article will give a general overview and address the recent innovations and applications of spectroscopic methods as PAT tools in the downstream processing of biologics. As data analysis strategies are a crucial part of PAT, the review discusses frequently used data analysis techniques and addresses data fusion methodologies as the combination of several sensors is moving forward in the field. The last chapter will give an outlook on the application of spectroscopic methods in combination with chemometrics and model predictive control (MPC) for downstream processes. Graphical abstract.
Identifiants
pubmed: 32146498
doi: 10.1007/s00216-020-02407-z
pii: 10.1007/s00216-020-02407-z
pmc: PMC7072065
doi:
Substances chimiques
Biological Products
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2047-2064Références
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