The influence of gene-chronic hepatitis C virus infection on hepatic fibrosis and steatosis.
Adult
Aged
Brazil
Carrier Proteins
/ genetics
Fatty Liver
/ genetics
Female
Genetic Association Studies
Genotype
Hepacivirus
/ genetics
Hepatitis C, Chronic
/ genetics
Humans
Interferons
/ genetics
Lipase
/ genetics
Liver Cirrhosis
/ genetics
Male
Membrane Proteins
/ genetics
Middle Aged
Polymorphism, Single Nucleotide
Hepatitis C
Interferon lambda 3 and 4 (IFNL3/IFNL4)
Microsomal triglyceride transfer protein (MTTP)
Patatin-like phospholipase domain containing 3 (PNPLA3)
Single nucleotide polymorphisms (SNPs)
Transmembrane six superfamily member 2 (TM6SF2)
Journal
Diagnostic microbiology and infectious disease
ISSN: 1879-0070
Titre abrégé: Diagn Microbiol Infect Dis
Pays: United States
ID NLM: 8305899
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
10
10
2019
revised:
24
01
2020
accepted:
14
02
2020
pubmed:
10
3
2020
medline:
28
11
2020
entrez:
10
3
2020
Statut:
ppublish
Résumé
Host single nucleotide polymorphisms (SNPs) in different genes can play a role in chronic hepatitis C virus (HCV) infection and influence the presence of hepatic fibrosis and comorbidities such as hepatic steatosis. We assessed the combined effect of SNPs in the PNPLA3, MTTP, TM6SF2, and IFNL3/IFNL4 genes in 288 Brazilian patients who were chronically infected with HCV. Hepatic fibrosis was observed in 246 (85.4%) patients and hepatic steatosis in 141 (49.0%) patients. PNPLA3 rs738409 (CG/GG) (P = 0.044) and TM6SF2 rs58542926 (CT) (P = 0.004) were alone associated with fibrosis, and PNPLA3 rs738409 (P < 0.05, in distinct genetic models) was associated with steatosis. Multiple logistic regression of each SNP combined with HCV genotype 3 infection showed that MTTP rs1800591 (GT/TT) combined with HCV genotype 3 was associated with a 6.72-fold increased chance of hepatic steatosis (P = 0.013). In the analysis of SNPs combined 2 by 2, no influence on hepatic fibrosis or steatosis was observed.
Identifiants
pubmed: 32147132
pii: S0732-8893(19)31018-1
doi: 10.1016/j.diagmicrobio.2020.115025
pii:
doi:
Substances chimiques
Carrier Proteins
0
interferon-lambda, human
0
Membrane Proteins
0
TM6SF2 protein, human
0
microsomal triglyceride transfer protein
0
Interferons
9008-11-1
Lipase
EC 3.1.1.3
adiponutrin, human
EC 3.1.1.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115025Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.