Long-standing multiple sclerosis neurodegeneration: volumetric magnetic resonance imaging comparison to Parkinson's disease, mild cognitive impairment, Alzheimer's disease, and elderly healthy controls.
Aged
Aged, 80 and over
Alzheimer Disease
/ diagnostic imaging
Atrophy
Brain
/ diagnostic imaging
Female
Healthy Aging
/ pathology
Humans
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Multiple Sclerosis
/ diagnostic imaging
Organ Size
Parkinson Disease
/ diagnostic imaging
Thalamus
/ diagnostic imaging
Alzheimer’s disease
Deep gray matter
MRI
Multiple sclerosis
Neurodegeneration
Parkinson’s disease
Thalamus
Whole brain atrophy
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
09
10
2019
revised:
30
01
2020
accepted:
03
02
2020
pubmed:
10
3
2020
medline:
30
10
2020
entrez:
10
3
2020
Statut:
ppublish
Résumé
Multiple sclerosis (MS) exhibits neurodegeneration driven disability progression. We compared the extent of neurodegeneration among 112 long-standing MS patients, 37 Parkinson's disease (PD) patients, 34 amnestic mild cognitive impairment (aMCI) patients, 37 Alzheimer's disease (AD) patients, and 184 healthy controls. 3T MRI volumes of whole brain (WBV), white matter (WMV), gray matter (GMV), cortical (CV), deep gray matter (DGM), and nuclei-specific volumes of thalamus, caudate, putamen, globus pallidus, and hippocampus were derived with SIENAX and FIRST software. Аge and sex-adjusted analysis of covariance was used. WBV was not significantly different between diseases. MS had significantly lower WMV compared to other disease groups (p < 0.021). Only AD had smaller GMV and CV when compared to MS (both p < 0.001). MS had smaller DGM volume than PD and aMCI (p < 0.001 and p = 0.026, respectively) and lower thalamic volume when compared to all other neurodegenerative diseases (p < 0.008). Long-standing MS exhibits comparable global atrophy with lower WMV and thalamic volume when compared to other classical neurodegenerative diseases.
Identifiants
pubmed: 32147244
pii: S0197-4580(20)30029-4
doi: 10.1016/j.neurobiolaging.2020.02.002
pmc: PMC7166193
mid: NIHMS1568898
pii:
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
84-92Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001412
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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