Mechanically-induced osteophyte in the rat knee.

Animals Disease Models, Animal Hindlimb Joints Mechanical Phenomena Osteophyte / etiology Rats Rats, Sprague-Dawley
Animal model Mechanical stress Osteoarthritis Osteophyte

Journal

Osteoarthritis and cartilage
ISSN: 1522-9653
Titre abrégé: Osteoarthritis Cartilage
Pays: England
ID NLM: 9305697

Informations de publication

Date de publication:
06 2020
Historique:
received: 15 08 2019
revised: 11 02 2020
accepted: 17 02 2020
pubmed: 10 3 2020
medline: 20 7 2021
entrez: 10 3 2020
Statut: ppublish

Résumé

Osteophytes are common anatomical signs of advanced osteoarthritis. It remains unclear whether they develop from physio-molecular, and/or mechanical stimuli. This study examined the effects of mechanical impact on the knee joint periosteum leading to osteophyte formation. Eighteen mature rats received one single impact load of 53 N (30 MPa) to the periosteum of the experimental medial femoral condyles. Contralateral knees were used as controls. Animals were sacrificed at 24 h, 3, 6 and 9 weeks post-impact. Distal femurs were harvested and prepared for histology. Hematoxylin and Eosin, and Masson's trichrome stained slides were examined by light microscopy. Nuclear density was quantified to assess the tissue reaction. 24 h: The synovium membrane, fibrous and cambium periosteum were damaged. Blood infiltration pooled in the impacted medial collateral ligament (MCL) region. Week 3: A cartilaginous tissue spur, chondrophyte, was found in every rat at the impacted site of the MCL. Chondrophytes were composed of fibrocartilage and cartilage matrix, with signs of cartilage mineralization and remodelling activity. Week 6: Chondrophytes presented signs of more advanced mineralisation, recognized as osteophytes. Week 9: Osteophytes appeared to be more mineralized with almost no cartilage tissue. Osteophytes can be induced with a single mechanical impact applied to the periosteum in rat knees. These data indicate that a moderate trauma to the periosteal layer of the joint may play a role in osteophyte development.

Identifiants

DOI: 10.1016/j.joca.2020.02.834 PMID: 32147535
pubmed: 32147535
pii: S1063-4584(20)30907-9
doi: 10.1016/j.joca.2020.02.834
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

853-864

Informations de copyright

Copyright © 2020 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Auteurs

G Venne (G)

Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada; 3640, Rue University, Montréal, QC, H3A 0C7, Canada. Electronic address: gabriel.venne@mcgill.ca.

M Y Tse (MY)

Department Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

S C Pang (SC)

Department Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

R E Ellis (RE)

Department Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada; Human Mobility Research Center, Kingston General Hospital, 76 Stuart Street, Kingston, ON, K7L 2V7, Canada; Department of Surgery, Queen's University, Kingston, ON, Canada; Kingston General Hospital, Kingston, ON, Canada; Department of Mechanical and Materials Engineering, Queen's University, Kingston, ON, Canada; School of Computing, Queen's University, Kingston, ON, Canada.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mechanically-induced osteophyte in the rat knee.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Mechanically-induced osteophyte in the rat knee.
questionsmedicales.fr › Structures anatomiques de l'animal › Membre pelvien › Mechanically-induced osteophyte in the rat knee.
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Mechanically-induced osteophyte in the rat knee.
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Mechanically-induced osteophyte in the rat knee.
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Hyperostose › Exostoses › Ostéophyte › Mechanically-induced osteophyte in the rat knee.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Mechanically-induced osteophyte in the rat knee.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Mechanically-induced osteophyte in the rat knee.