The effects of ginger supplementation on markers of inflammatory and oxidative stress: A systematic review and meta-analysis of clinical trials.
Ginger
Inflammation
Meta-analysis
Oxidative stress
Zingiber
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
22
11
2019
revised:
30
12
2019
accepted:
29
01
2020
pubmed:
10
3
2020
medline:
30
9
2020
entrez:
10
3
2020
Statut:
ppublish
Résumé
The present systematic review and meta-analysis was conducted to investigate the effects of ginger supplementation on markers of inflammatory and oxidative stress. PubMed, Embase, Scopus, and Web of Science were systematically searched to identify relevant clinical trials evaluating the effects of ginger on serum CRP (C-reactive protein), TNF-α (tumor necrosis factor-alpha), IL-6 (interleukin-6), PGE2 (prostaglandin E2), TAC (total antioxidant capacity), and MDA (malondialdehyde) from inception up to September 2019. Mean difference and 95% confidence intervals were pooled using a random-effects model. Potential publication bias was assessed using visual inspection of funnel plot and Egger's weighted regression tests. After excluding irrelevant records, 20 full-text articles that included 25 separate studies were included to the meta-analysis. Pooled results of this study indicated a statistically significant effect of ginger on serum CRP, TNF-α, IL-6, TAC, and MDA levels following ginger supplementation in compared to the controls. Also, the effects of ginger on serum PGE2 was marginally significant. Moreover, the high heterogeneity was disappeared in subgroup analysis performed by age, duration, dosage, and quality. This current analysis indicates that ginger supplementation has a significant effects on serum inflammatory and oxidative stress markers.
Substances chimiques
Biomarkers
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1723-1733Informations de copyright
© 2020 John Wiley & Sons, Ltd.
Références
Al Hroob, A. M., Abukhalil, M. H., Alghonmeen, R. D., & Mahmoud, A. M. (2018). Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy. Biomedicine & Pharmacotherapy, 106, 381-389.
Ali, B. H., Blunden, G., Tanira, M. O., & Nemmar, A. (2008). Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology, 46(2), 409-420.
Arablou, T., Aryaeian, N., Valizadeh, M., Sharifi, F., Hosseini, A., & Djalali, M. (2014). The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. International Journal of Food Sciences and Nutrition, 65(4), 515-520. https://doi.org/10.3109/09637486.2014.880671
Arabzadegan, N., Daneshzad, E., Fatahi, S., Moosavian, S. P., Surkan, P. J., & Azadbakht, L. (2019). Effects of dietary whole grain, fruit, and vegetables on weight and inflammatory biomarkers in overweight and obese women. Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity, 10(4), 1-9.
Aryaeian, N., & Tavakkoli, H. (2015). Ginger and its effects on inflammatory diseases. Food Technology and Nutritional Sciences, 1(4), 97-101.
Atashak, S., Peeri, M., Azarbayjani, M. A., Stannard, S. R., & Haghighi, M. M. (2011). Obesity-related cardiovascular risk factors after long- term resistance training and ginger supplementation. Journal of Sports Science and Medicine, 10(4), 685-691.
Attia, A. M., Ibrahim, F. A., Nabil, G. M., & Aziz, S. W. (2013). Antioxidant effects of whole ginger (Zingiber officinale Roscoe) against lead acetate-induced hematotoxicity in rats. Journal of Medicinal Plants Research, 7(17), 1108-1113.
Ayaz, A., & Roshan, V. D. (2012). Effects of 6-weeks water-based intermittent exercise with and without Zingiber officinale on pro-inflammatory markers and blood lipids in overweight women with breast cancer. Journal of Applied Pharmaceutical Science, 2(5), 218-224. https://doi.org/10.7324/JAPS.2012.2547
Azimi, P., Ghiasvand, R., Feizi, A., Hariri, M., & Abbasi, B. (2014). Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes patients. The Review of Diabetic Studies, 11(3-4), 258-266. https://doi.org/10.1900/rds.2014.11.258
Baliga, M. S., Haniadka, R., Pereira, M. M., D'Souza, J. J., Pallaty, P. L., Bhat, H. P., & Popuri, S. (2011). Update on the chemopreventive effects of ginger and its phytochemicals. Critical Reviews in Food Science and Nutrition, 51(6), 499-523.
Black, C. D., Herring, M. P., Hurley, D. J., & O'Connor, P. J. (2010). Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. The Journal of Pain, 11(9), 894-903. https://doi.org/10.1016/j.jpain.2009.12.013
Clark, H. D., Wells, G. A., Huët, C., McAlister, F. A., Salmi, L. R., Fergusson, D., & Laupacis, A. J. C. c. t. (1999). Assessing the quality of randomized trials. Reliability of the Jadad Scale, 20(5), 448-452.
Daenen, K., Andries, A., Mekahli, D., Van Schepdael, A., Jouret, F., & Bammens, B. (2019). Oxidative stress in chronic kidney disease. Pediatric Nephrology, 34(6), 975-991.
Di Rosanna, P., & Salvatore, C. (2012). Reactive oxygen species, inflammation, and lung diseases. Current Pharmaceutical Design, 18(26), 3889-3900.
Donath, M. Y. (2019). Inflammation and type 2 diabetes: From basic science to treatment. Paper presented at the Seminars in immunopathology.
Gabay, C. (2006). Interleukin-6 and chronic inflammation. Arthritis Research & Therapy, 8(2), S3.
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010). Immunity, inflammation, and cancer. Cell, 140(6), 883-899.
Guarner, V., & Rubio-Ruiz, M. E. (2015). Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease. In Aging and health-A systems biology perspective (Vol. 40, pp. 99-106). Karger Publishers.
Harizi, H., Corcuff, J.-B., & Gualde, N. (2008). Arachidonic-acid-derived eicosanoids: Roles in biology and immunopathology. Trends in Molecular Medicine, 14(10), 461-469.
Hunninghake, G. W., Garrett, K. C., Richerson, H. B., Fantone, J. C., Ward, P. A., Rennard, S. I., … Crystal, R. G. (1984). Pathogenesis of the granulomatous lung diseases. American Review of Respiratory Disease, 130(3), 476-477.
Imani, H., Tabibi, H., Najafi, I., Atabak, S., Hedayati, M., & Rahmani, L. J. N. (2015). Effects of ginger on serum glucose, advanced glycation end products, and inflammation in peritoneal dialysis patients. Nutrition, 31(5), 703-707.
Kafeshani, M. (2015). Ginger, micro-inflammation and kidney disease. Nutrition, 31, 703-707.
Kim, S. O., Chun, K. S., Kundu, J. K., & Surh, Y. J. (2004). Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-κB and p38 MAPK in mouse skin. BioFactors, 21(1-4), 27-31.
Kulkarni, R. A., & Deshpande, A. R. (2016). Anti-inflammatory and antioxidant effect of ginger in tuberculosis. Journal of Complementary and Integrative Medicine, 13(2), 201-206. https://doi.org/10.1515/jcim-2015-0032
Kumar, S., Singh, U., Saxena, K., & Saxena, R. J. I. J. H. M. (2013). Supplementation of ginger with anti-tuberculosis treatment (ATT): A better approach to treat anemic pulmonary tuberculosis patients. International Journal of Herbal Medicine, 1, 17-20.
Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., … Bonaduce, D. (2018). Oxidative stress, aging, and diseases. Clinical Interventions in Aging, 13, 757-772.
Luettig, J., Rosenthal, R., Lee, I. F. M., Krug, S. M., & Schulzke, J. D. (2016). The ginger component 6-shogaol prevents TNF-α-induced barrier loss via inhibition of PI3K/Akt and NF-κB signaling. Molecular Nutrition & Food Research, 60(12), 2576-2586.
Mahluji, S., Ostadrahimi, A., Mobasseri, M., Ebrahimzade Attari, V., & Payahoo, L. (2013). Anti-inflammatory effects of Zingiber officinale in type 2 diabetic patients. Advanced Pharmaceutical Bulletin, 3(2), 273-276. https://doi.org/10.5681/apb.2013.044
Mao, Q.-Q., Xu, X.-Y., Cao, S.-Y., Gan, R.-Y., Corke, H., & Li, H.-B. (2019). Bioactive compounds and bioactivities of ginger (Zingiber officinale roscoe). Food, 8(6), 185.
Mashhadi, N. S., Ghiasvand, R., Askari, G., Hariri, M., Darvishi, L., & Mofid, M. R. (2013). Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: Review of current evidence. International Journal of Preventive Medicine, 4(Suppl 1), S36.
Mazidi, M., Gao, H.-K., Rezaie, P., & Ferns, G. A. (2016). The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: A systematic review and meta-analysis. Food & Nutrition Research, 60(1), 32613.
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & PRISMA Group. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLOS Medicine, 151(4), 264-269.
Mozaffari-Khosravi, H., Naderi, Z., Dehghan, A., Nadjarzadeh, A., & Fallah Huseini, H. (2016). Effect of ginger supplementation on Proinflammatory cytokines in older patients with osteoarthritis: Outcomes of a randomized controlled clinical trial. Journal of Nutrition in Gerontology and Geriatrics, 35(3), 209-218. https://doi.org/10.1080/21551197.2016.1206762
Naderi, Z., Mozaffari-Khosravi, H., Dehghan, A., Nadjarzadeh, A., & Huseini, H. F. (2016). Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial. Journal of Traditional and Complementary Medicine, 6(3), 199-203. https://doi.org/10.1016/j.jtcme.2014.12.007
Pastori, D., Carnevale, R., Bartimoccia, S., Nocella, C., Tanzilli, G., Cangemi, R., … Pignatelli, P. (2015). Does Mediterranean diet reduce cardiovascular events and oxidative stress in atrial fibrillation? New Rochelle, NY: Mary Ann Liebert, Inc.
Pepys, M. B., & Hirschfield, G. M. (2003). C-reactive protein: A critical update. The Journal of Clinical Investigation, 111(12), 1805-1812.
Phan, P. V., Sohrabi, A., Polotsky, A., Hungerford, D. S., Lindmark, L., & Frondoza, C. G. (2005). Ginger extract components suppress induction of chemokine expression in human synoviocytes. Journal of Alternative & Complementary Medicine, 11(1), 149-154.
Rahimlou, M., Yari, Z., Hekmatdoost, A., Alavian, S. M., & Keshavarz, S. A. (2016). Ginger supplementation in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled pilot study. Hepatitis Monthly, 16(1), e34897. https://doi.org/10.5812/hepatmon.34897
Safranow, K., Dziedziejko, V., Rzeuski, R., Czyżycka, E., Bukowska, H., Wojtarowicz, A., … Ciechanowicz, A. (2016). Inflammation markers are associated with metabolic syndrome and ventricular arrhythmia in patients with coronary artery disease. Advances in Hygiene & Experimental Medicine/Postepy Higieny i Medycyny Doswiadczalnej, 70, 55-66.
Sahebkar, A. (2011). Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. World Journal of Gastroenterology, 17(2), 271-272.
Sherif, M. H., Abas, A.-S. M., & Zaitoun, L. A. (2018). Ginger extract protect iodinated contrast media nephrotoxicity in rats through modulation of oxidative stress, cystain C, NGAL and TNF α. Research Journal of Pharmacy and Technology, 11(12), 5439-5448.
Shidfar, F., Rajab, A., Rahideh, T., Khandouzi, N., Hosseini, S., & Shidfar, S. (2015). The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. Journal of Complementary and Integrative Medicine, 12(2), 165-170. https://doi.org/10.1515/jcim-2014-0021
Stanley, T. L., Zanni, M. V., Johnsen, S., Rasheed, S., Makimura, H., Lee, H., … Grinspoon, S. K. (2011). TNF-α antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome. The Journal of Clinical Endocrinology & Metabolism, 96(1), E146-E150.
Suk, S., Kwon, G. T., Lee, E., Jang, W. J., Yang, H., Kim, J. H., … Lee, K. W. (2017). Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. Molecular Nutrition & Food Research, 61(10), 1700139.
Thomson, M., Al-Qattan, K., Al-Sawan, S., Alnaqeeb, M., Khan, I., & Ali, M. (2002). The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins, Leukotrienes and Essential Fatty Acids, 67(6), 475-478.
Tsuge, K., Inazumi, T., Shimamoto, A., & Sugimoto, Y. (2019). Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases. International Immunology, 31(9), 597-606.
Tufanaru, C., Munn, Z., Stephenson, M., & Aromataris, E. (2015). Fixed or random effects meta-analysis? Common methodological issues in systematic reviews of effectiveness. International journal of evidence-based healthcare, 13(3), 196-207.
Vahdat Shariatpanahi, Z., Mokhtari, M., Taleban, F. A., Alavi, F., Salehi Surmaghi, M. H., Mehrabi, Y., & Shahbazi, S. (2013). Effect of enteral feeding with ginger extract in acute respiratory distress syndrome. Journal of Critical Care, 28(2), 217.e211-216. https://doi.org/10.1016/j.jcrc.2012.04.017
Wang, J., Ke, W., Bao, R., Hu, X., & Chen, F. (2017). Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: A review. Annals of the New York Academy of Sciences, 1398(1), 83-98.
Zehsaz, F., Farhangi, N., & Mirheidari, L. (2014). The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners. Central-European Journal of Immunology, 39(2), 174-180. https://doi.org/10.5114/ceji.2014.43719
Zick, S. M., Turgeon, D. K., Ren, J., Ruffin, M. T., Wright, B. D., Sen, A., … Brenner, D. E. (2015). Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer. Molecular Carcinogenesis, 54(9), 908-915. https://doi.org/10.1002/mc.22163