Association of Interleukin-1 and Inteleukin-1 Receptor Antagonist Gene Polymorphisms with Multiple Sclerosis in Azeri Population of Iran.
Adult
Case-Control Studies
Feeding Behavior
/ physiology
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Interleukin 1 Receptor Antagonist Protein
/ genetics
Interleukin-1
/ genetics
Iran
/ epidemiology
Male
Multiple Sclerosis
/ epidemiology
Polymorphism, Single Nucleotide
Young Adult
IL-1A
IL-1B
IL-1RA
Iran.
multiple sclerosis
polymorphism
Journal
Endocrine, metabolic & immune disorders drug targets
ISSN: 2212-3873
Titre abrégé: Endocr Metab Immune Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269157
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
10
2019
revised:
14
01
2020
accepted:
14
01
2020
pubmed:
10
3
2020
medline:
16
6
2021
entrez:
10
3
2020
Statut:
ppublish
Résumé
Cytokines as important mediators have a critical role in appropriate immune responses, the irregular production of which can lead to Multiple Sclerosis (MS). Proinflammatory cytokine interleukin-1 (IL-1) triggers inflammatory responses. Function and production of the cytokine are influenced by IL-1 coding gene polymorphism and those antagonists gene polymorphism. The aim of the present study was to evaluate the possible correlation between MS and IL-1 related alleles in Azeri population of Iran. Variable number tandem repeats (VNTR) genotypes of 150 MS patients and 220 healthy non-relative controls were determined. In the healthy controls, genotype TT at IL-1A (-889) location was significantly higher than the MS patients (p=0.0001). However, a significant difference was not found between the two groups in genotypic/allelic frequency at IL- 1B+ 3953 location. Evaluation of the IL-1RA gene revealed that genotype 1/2, and genotype 1/3 were significantly higher in the healthy controls and MS patients, respectively. Our findings indicated that the consumption of fast-food in MS patients was significantly higher than controls (p= <0.05). Also, a considerable number of MS patients had inappropriate dieting behaviors such as not eating breakfast (p= 0.0001), and irregular eating habits (p= 0.0001). Polymorphisms of the IL-1B genes and common alleles of IL-1RA were not considered as risk factors for MS disease. However, genotype TT at IL-1A (-889) location and the rare allele of IL-1RA3 can be a potential risk factor for the disease. Furthermore, inappropriate dieting behaviors and consumption of fast-food can increase the risk of MS.
Sections du résumé
BACKGROUND
BACKGROUND
Cytokines as important mediators have a critical role in appropriate immune responses, the irregular production of which can lead to Multiple Sclerosis (MS). Proinflammatory cytokine interleukin-1 (IL-1) triggers inflammatory responses. Function and production of the cytokine are influenced by IL-1 coding gene polymorphism and those antagonists gene polymorphism.
OBJECTIVE
OBJECTIVE
The aim of the present study was to evaluate the possible correlation between MS and IL-1 related alleles in Azeri population of Iran.
METHODS
METHODS
Variable number tandem repeats (VNTR) genotypes of 150 MS patients and 220 healthy non-relative controls were determined.
RESULTS
RESULTS
In the healthy controls, genotype TT at IL-1A (-889) location was significantly higher than the MS patients (p=0.0001). However, a significant difference was not found between the two groups in genotypic/allelic frequency at IL- 1B+ 3953 location. Evaluation of the IL-1RA gene revealed that genotype 1/2, and genotype 1/3 were significantly higher in the healthy controls and MS patients, respectively. Our findings indicated that the consumption of fast-food in MS patients was significantly higher than controls (p= <0.05). Also, a considerable number of MS patients had inappropriate dieting behaviors such as not eating breakfast (p= 0.0001), and irregular eating habits (p= 0.0001).
CONCLUSION
CONCLUSIONS
Polymorphisms of the IL-1B genes and common alleles of IL-1RA were not considered as risk factors for MS disease. However, genotype TT at IL-1A (-889) location and the rare allele of IL-1RA3 can be a potential risk factor for the disease. Furthermore, inappropriate dieting behaviors and consumption of fast-food can increase the risk of MS.
Identifiants
pubmed: 32148206
pii: EMIDDT-EPUB-105091
doi: 10.2174/1871530320666200309142541
doi:
Substances chimiques
IL1RN protein, human
0
Interleukin 1 Receptor Antagonist Protein
0
Interleukin-1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1110-1116Informations de copyright
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