Correlation between Immunohistochemical and Histomorphological Features of Ampullary Carcinomas: A Study on 72 Cases from a Tertiary Health Care Center.
Journal
Gastroenterology research and practice
ISSN: 1687-6121
Titre abrégé: Gastroenterol Res Pract
Pays: Egypt
ID NLM: 101475557
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
09
2019
accepted:
22
10
2019
entrez:
10
3
2020
pubmed:
10
3
2020
medline:
10
3
2020
Statut:
epublish
Résumé
Tumors involving the ampulla could be arising primarily in the ampulla or extending from the adjacent. When a neoplasm is centered primarily in the ampulla with or without periampullary mucosal involvement, it is considered a primary ampullary carcinoma. These tumors generally have a better prognosis than duodenal and pancreaticobiliary neoplasms secondarily involving the ampulla. Distinguishing between the two primary types has prognostic implications, as the pancreaticobiliary-type ampullary carcinomas are said to have a poorer prognosis than the intestinal-type. Morphological analysis alone may not suffice in this context. The role of immunohistochemistry has therefore been explored by various groups of workers. The purpose of the present study was to determine the role of morphology and cytokeratin profile in accurate typing of ampullary carcinomas as intestinal and pancreaticobiliary.
Identifiants
pubmed: 32148475
doi: 10.1155/2020/2080351
pmc: PMC7057012
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2080351Informations de copyright
Copyright © 2020 Usha Mary Abraham and Subramaniam Ramkumar.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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