The effect of zinc supplementation on pro-inflammatory cytokines (TNF-α, IL-1 AND IL-6) in mice with
Diarrhea
Interleukin 1
Interleukin 6
Tumor necrosis factor-α
Zinc
Journal
Iranian journal of microbiology
ISSN: 2008-3289
Titre abrégé: Iran J Microbiol
Pays: Iran
ID NLM: 101518404
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
entrez:
10
3
2020
pubmed:
10
3
2020
medline:
10
3
2020
Statut:
ppublish
Résumé
Inflammation in the intestine causes diarrhea due to an increased release of pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6. These are triggered by the exposure of This study used a controlled trial experimental design in the laboratory. A sample size of 20 mice were randomly divided into 4 groups: 1) Control group was given standard foods, 2) Trial group was given Positive effects of zinc supplementation on levels of pro-inflammatory cytokines were observed, in which the higher levels of zinc were present, the lower levels of pro-inflammatory cytokines, especially TNF-α were observed. However, there was an increase of IL-1 and IL-6 levels on the 8 Oral zinc supplementation had a significant positive effect on the levels of pro-inflammatory cytokines. Where there were higher levels of zinc, lower levels of pro-inflammatory cytokines TNF-α were present.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Inflammation in the intestine causes diarrhea due to an increased release of pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6. These are triggered by the exposure of
MATERIALS AND METHODS
METHODS
This study used a controlled trial experimental design in the laboratory. A sample size of 20 mice were randomly divided into 4 groups: 1) Control group was given standard foods, 2) Trial group was given
RESULTS
RESULTS
Positive effects of zinc supplementation on levels of pro-inflammatory cytokines were observed, in which the higher levels of zinc were present, the lower levels of pro-inflammatory cytokines, especially TNF-α were observed. However, there was an increase of IL-1 and IL-6 levels on the 8
CONCLUSION
CONCLUSIONS
Oral zinc supplementation had a significant positive effect on the levels of pro-inflammatory cytokines. Where there were higher levels of zinc, lower levels of pro-inflammatory cytokines TNF-α were present.
Types de publication
Journal Article
Langues
eng
Pagination
412-418Informations de copyright
Copyright© 2019 Iranian Neuroscience Society.
Références
Nutrients. 2017 Jun 17;9(6):
pubmed: 28629136
Mol Med. 2008 May-Jun;14(5-6):353-7
pubmed: 18385818
Indian J Pediatr. 2006 Jun;73(6):493-7
pubmed: 16816510
Am J Clin Nutr. 1990 Jul;52(1):173-7
pubmed: 2360547
Am J Clin Nutr. 1998 Aug;68(2 Suppl):447S-463S
pubmed: 9701160
Am J Clin Nutr. 1997 Aug;66(2):464S-477S
pubmed: 9250134
J Nutr. 2003 May;133(5 Suppl 1):1452S-6S
pubmed: 12730441
Pediatrics. 2007 Jun;119(6):1120-30
pubmed: 17545379
Mol Nutr Food Res. 2015 May;59(5):991-9
pubmed: 25656040
Annu Rev Immunol. 1993;11:165-90
pubmed: 8386517
J Pediatr Gastroenterol Nutr. 1992 Oct;15(3):289-96
pubmed: 1432467
J Physiol Sci. 2018 Jan;68(1):19-31
pubmed: 28965330
Pediatrics. 2002 Jun;109(6):e86
pubmed: 12042580
Microbiol Immunol. 1998;42(9):591-8
pubmed: 9802559
J Immunol Res. 2018 Nov 25;2018:5749120
pubmed: 30596108