The essentials of developmental apoptosis.
A1
APAF-1
BAD
BAK
BAX
BCL-2
BCL-W
BCL-XL
BID
BIK
BIM
BMF
BOK
Embryo
HRK
MCL-1
NOXA
PUMA
apoptosis
caspases
development
fetus
programmed cell death
Journal
F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320
Informations de publication
Date de publication:
2020
2020
Historique:
accepted:
19
02
2020
entrez:
10
3
2020
pubmed:
10
3
2020
medline:
29
7
2020
Statut:
epublish
Résumé
Apoptotic cells are commonly observed in a broad range of tissues during mammalian embryonic and fetal development. Specific requirements and functions of programmed cell death were inferred from early observations. These inferences did not hold up to functional proof for a requirement of apoptosis for normal tissue development in all cases. In this review, we summarize how the appraisal of the importance of developmental apoptosis has changed over the years, in particular with detailed functional assessment, such as by using gene-targeted mice lacking essential initiators or mediators of apoptosis. In recent years, the essentials of developmental apoptosis have emerged. We hypothesize that apoptosis is predominantly required to balance cell proliferation. The two interdependent processes-cell proliferation and apoptosis-together more powerfully regulate tissue growth than does each process alone. We proposed that this ensures that tissues and cell populations attain the appropriate size that allows fusion in the body midline and retain the size of cavities once formed. In addition, a limited number of tissues, albeit not all previously proposed, rely on apoptosis for remodeling, chiefly aortic arch remodeling, elimination of supernumerary neurons, removal of vaginal septa, and removal of interdigital webs in the formation of hands and feet.
Identifiants
pubmed: 32148779
doi: 10.12688/f1000research.21571.1
pmc: PMC7047912
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright: © 2020 Voss AK and Strasser A.
Déclaration de conflit d'intérêts
No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.
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