Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
Journal
Journal of aging research
ISSN: 2090-2204
Titre abrégé: J Aging Res
Pays: United States
ID NLM: 101543460
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
05
2019
revised:
20
11
2019
accepted:
26
12
2019
entrez:
10
3
2020
pubmed:
10
3
2020
medline:
10
3
2020
Statut:
epublish
Résumé
Recent studies have suggested that vitamin K may exert significant effects on the central nervous system. The present study investigates the relationship between vitamin K plasmatic levels and cognitive functions in elderly patients on oral anticoagulant therapy (OAT). At the Thrombosis Centre of Haematology, "Sapienza" University of Rome, 85 patients on OAT, aged between 75 and 92, were randomly enrolled in the study. Patients were on OAT with vitamin K antagonists (VKAs). Vitamin K1 concentrations were determined using standardized High-Performance Liquid Chromatography (HPLC). Cognitive functions were assessed using the Milan Overall Dementia Assessment (MODA). MODA scores are positively correlated to vitamin K1 concentration. Patients with vitamin K1 below 0.100 The study shows a positive association between vitamin K1 concentration and cognitive status in elderly patients (≥75 years) on OAT. The relationship between vitamin K1 concentration and MODA scores is described by a linear model. Cognitive status is not influenced by the duration of OAT but by the years of education.
Identifiants
pubmed: 32148962
doi: 10.1155/2020/9695324
pmc: PMC7049843
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9695324Informations de copyright
Copyright © 2020 Ludovico Alisi et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this paper.
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