HNK-1 sulfotransferase modulates α-dystroglycan glycosylation by 3-O-sulfation of glucuronic acid on matriglycan.

Animals Dystroglycans / chemistry Glucuronic Acid / chemistry Glycosylation Mice Sulfotransferases / chemistry
O-mannosylation congenital muscular dystrophy glycosylation sulfotransferase α-dystroglycan

Journal

Glycobiology
ISSN: 1460-2423
Titre abrégé: Glycobiology
Pays: England
ID NLM: 9104124

Informations de publication

Date de publication:
28 09 2020
Historique:
received: 14 07 2019
revised: 26 02 2020
accepted: 26 02 2020
pubmed: 10 3 2020
medline: 28 10 2021
entrez: 10 3 2020
Statut: ppublish

Résumé

Mutations in multiple genes required for proper O-mannosylation of α-dystroglycan are causal for congenital/limb-girdle muscular dystrophies and abnormal brain development in mammals. Previously, we and others further elucidated the functional O-mannose glycan structure that is terminated by matriglycan, [(-GlcA-β3-Xyl-α3-)n]. This repeating disaccharide serves as a receptor for proteins in the extracellular matrix. Here, we demonstrate in vitro that HNK-1 sulfotransferase (HNK-1ST/carbohydrate sulfotransferase) sulfates terminal glucuronyl residues of matriglycan at the 3-hydroxyl and prevents further matriglycan polymerization by the LARGE1 glycosyltransferase. While α-dystroglycan isolated from mouse heart and kidney is susceptible to exoglycosidase digestion of matriglycan, the functional, lower molecular weight α-dystroglycan detected in brain, where HNK-1ST expression is elevated, is resistant. Removal of the sulfate cap by a sulfatase facilitated dual-glycosidase digestion. Our data strongly support a tissue specific mechanism in which HNK-1ST regulates polymer length by competing with LARGE for the 3-position on the nonreducing GlcA of matriglycan.

Identifiants

DOI: 10.1093/glycob/cwaa024 PMID: 32149355 PMC: PMC7673472
pubmed: 32149355
pii: 5788508
doi: 10.1093/glycob/cwaa024
pmc: PMC7673472
doi:

Substances chimiques

Dystroglycans 146888-27-9
Glucuronic Acid 8A5D83Q4RW
HNK-1 sulfotransferase EC 2.8.2.-
Sulfotransferases EC 2.8.2.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

817-829

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM111939
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103390
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103490
Pays : United States
Organisme : NINDS NIH HHS
ID : P50 NS053672
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM107012
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS053672
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM130915
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Auteurs

M Osman Sheikh (MO)

Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.

David Venzke (D)

Department of Molecular Physiology and Biophysics, Department of Neurology, Howard Hughes Medical Institute, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA.

Mary E Anderson (ME)

Department of Molecular Physiology and Biophysics, Department of Neurology, Howard Hughes Medical Institute, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA.

Takako Yoshida-Moriguchi (T)

Department of Molecular Physiology and Biophysics, Department of Neurology, Howard Hughes Medical Institute, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA.

John N Glushka (JN)

Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.

Alison V Nairn (AV)

Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.

Melina Galizzi (M)

Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.

Kelley W Moremen (KW)

Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.

Kevin P Campbell (KP)

Department of Molecular Physiology and Biophysics, Department of Neurology, Howard Hughes Medical Institute, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA.

Lance Wells (L)

Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › HNK-1 sulfotransferase modulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines associées à la dystrophine › Dystroglycanes › HNK-1 sulfotransferase modulates...
questionsmedicales.fr › Glucides › Oses acides › Acides uroniques › Glucuronates › Acide glucuronique › HNK-1 sulfotransferase modulates...
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Glycosylation › HNK-1 sulfotransferase modulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › HNK-1 sulfotransferase modulates...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Sulfur group transferases › Sulfotransferases › HNK-1 sulfotransferase modulates...