Role of Local Flaps to Achieve Primary Wound Closure in Medication-Related Osteonecrosis of the Jaws Osseous-Resective Surgery.
Journal
The Journal of craniofacial surgery
ISSN: 1536-3732
Titre abrégé: J Craniofac Surg
Pays: United States
ID NLM: 9010410
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
pubmed:
10
3
2020
medline:
21
10
2020
entrez:
10
3
2020
Statut:
ppublish
Résumé
The aim of the present work is to evaluate the most suitable surgical technique in relation to location and extent of medication-related osteonecrosis of the jaws (MRONJ) through comparison of success rate between the routinely used mucoperiostal flaps and different local flaps designs and propose a standardization of surgical procedures according to MRONJ stage and localization with 2 objectives: to provide the surgeon with an algorithm of treatment according to MRONJ localization and extension; to maximize the success of surgical treatment.Thirteen consecutive patients affected by focal MRONJ were surgically treated with radical osteotomy at the Center for Treatment of the Osteonecrosis of the Jaws (University of Messina, Italy).Initial defects were classified according to the classification of the Italian Societies of Oral Medicine and Maxillofacial Surgery (the SICMF-SIPMO staging system) which consider not only bone exposure but also radiological bone involvement. Treatment outcome was retrospectively assessed according to the different adopted surgical procedure: mucoperiostal flaps (GROUP A) advanced mucoperiostal flaps or rotation flaps (GROUP B) local flaps (GROUP C).Outcome after surgical treatment of focal MRONJ was positive in every group irrespective of MRONJ localization and extension. This may be due to the appropriate selection of surgical procedure.The results obtained demonstrated that focal MRONJ surgical treatment is a reliable procedure irrespective of the initial clinical situation. Radical osteotomy combined with appropriate selection of soft tissue management is crucial.
Identifiants
pubmed: 32149968
doi: 10.1097/SCS.0000000000006288
pii: 00001665-202006000-00082
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e347-e352Références
Beth-Tasdogan NH, Mayer B, Hussein H, et al. Interventions for managing medication-related osteonecrosis of the jaw. Cochrane Database Syst Rev 2017; 10:CD012432.
Wilde F, Heufelder M, Winter K, et al. The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 111:153–163.
Ristow O, Rückschloß T, Bodem J, et al. Double-layer closure techniques after bone surgery of medication-related osteonecrosis of the jaw—a single center cohort study. J Craniomaxillofac Surg 2018; 46:815–824.
Stockmann P, Vairaktaris E, Wehrhan F, et al. Osteotomy and primary wound closure in bisphosphonate-associated osteonecrosis of the jaw: a prospective clinical study with 12 months follow-up. Support Care Cancer 2010; 18:449–460.
Aljohani S, Troeltzsch M, Hafner S, et al. Surgical treatment of medication-related osteonecrosis of the upper jaw: case series. Oral Dis 2019; 25:497–507.
Mücke T, Koschinski J, Deppe H, et al. Outcome of treatment and parameters influencing recurrence in patients with bisphosphonate-related osteonecrosis of the jaws. J Cancer Res Clin Oncol 2011; 137:907–913.
Bedogni A, Fusco V, Agrillo A, et al. Learning from experience. Proposal of a refined definition and staging system for bisphosphonate- related osteonecrosis of the jaw (BRONJ). Oral Dis 2012; 18:621–623.
Bedogni A, Fedele S, Bedogni G, et al. Staging of osteonecrosis of the jaw requires computed tomography for accurate definition of the extent of bony disease. Br J Oral Maxillofac Surg 2014; 52:603–608.
Carlson ER, Basile JD. The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 2009; 67: (5 suppl): 85–95.
Wilde F, Hendricks J, Riese C, et al. Bone regeneration without bone grafting after resection of a segment of the mandible to treat bisphosphonate-related osteonecrosis of the jaw. J Oral Maxillofac Surg 2011; 69:2657–2662.
Kim HY, Lee SJ, Kim SM, et al. Extensive surgical procedures result in better treatment outcomes for bisphosphonate-related osteonecrosis of the jaw in patients with osteoporosis. J Oral Maxillofac Surg 2017; 75:1404–1413.
McLeod NM, Patel V, Kusanale A, et al. Bisphosphonate osteonecrosis of the jaw: a literature review of UK policies versus international policies on the management of bisphosphonate osteonecrosis of the jaw. Br J Oral Maxillofac Surg 2011; 49:335–342.
Bedogni A, Saia G, Bettini G, et al. Long-term outcomes of surgical resection of the jaws in cancer patients with bisphosphonate-related osteonecrosis. Oral Oncol 2011; 47:420–424.
Zirk M, Kreppel M, Buller J, et al. The impact of surgical intervention and antibiotics on MRONJ stage II and III—Retrospective study. J Craniomaxillofac Surg 2017; 45:1183–1189.
Voss PJ, Joshi Oshero J, Kovalova-Müller A, et al. Surgical treatment of bisphosphonate-associated osteonecrosis of the jaw: technical report and follow up of 21 patients. J Craniomaxillofac Surg 2012; 40:719–725.
Voss PJ, Vargas Soto G, Schmelzeisen R, et al. Sinusitis and oroantral fistula in patients with bisphosphonate-associated necrosis of the maxilla. Head Face Med 2016; 6:3.
Blus C, Giannelli G, Szmukler-Moncler S, et al. Treatment of medication-related osteonecrosis of the jaws (MRONJ) with ultrasonic piezoelectric bone surgery. A case series of 20 treated sites. Oral Maxillofac Surg 2017; 21:41–48.
Pichardo SE, van Merkesteyn JP. Evaluation of a surgical treatment of denosumab-related osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol 2016; 122:272–278.
Graziani F, Vescovi P, Campisi G, et al. Resective surgical approach shows a high performance in the management of advanced cases of bisphosphonate-related osteonecrosis of the jaws: a retrospective survey of 347 cases. J Oral Maxillofac Surg 2012; 70:2501–2507.
Schubert M, Klatte I, Linek W, et al. The saxon bisphosphonate register—therapy and prevention of bisphosphonate-related osteonecrosis of the jaws. Oral Oncol 2012; 48:349–354.
Stanton DC, Balasanian E. Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases. J Oral Maxillofac Surg 2009; 67:943–950.
Mücke T, Koerdt S, Jung M, et al. The role of mylohyoid flap in the treatment of bisphosphonate-related osteonecrosis of the jaws. J Craniomaxillofac Surg 2016; 44:369–373.
Lemound J, Eckardt A, Kokemüller H, et al. Bisphosphonate-associated osteonecrosis of the mandible: reliable soft tissue reconstruction using a local myofascial flap. Clin Oral Investig 2012; 16:1143–1152.
Gallego L, Junquera L, Pelaz A, et al. The use of pedicled buccal fat pad combined with sequestrectomy in bisphosphonate-related osteonecrosis of the maxilla. Med Oral Patol Oral Cir Bucal 2012; 17:e236–e241.
Berrone M, Florindi FU, Carbone V, et al. Stage 3 medication-related osteonecrosis of the posterior maxilla: surgical treatment using a pedicled buccal fat pad flap: case reports. J Oral Maxillofac Surg 2015; 73:2082–2086.
Rotaru H, Kim MK, Kim SG, et al. Pedicled buccal fat pad flap as a reliable surgical strategy for the treatment of medication-related osteonecrosis of the jaw. J Oral Maxillofac Surg 2015; 73:437–442.
Eguchi T, Kanai I, Basugi A, et al. The assessment of surgical and non-surgical treatment of stage II medication-related osteonecrosis of the jaw. Med Oral Patol Oral Cir Bucal 2017; 22:e788–e795.
Lemound J, Muecke T, Zeller AN, et al. Nasolabial flap improves healing in medication-related osteonecrosis of the jaw. J Oral Maxillofac Surg 2018; 76:877–885.
Kang MH, Lee DK, Kim CW, et al. Clinical characteristics and recurrence-related factors of medication-related osteonecrosis of the jaw. J Korean Assoc Oral Maxillofac Surg 2018; 44:225–231.
Bodem JP, Schaal C, Kargus S, et al. Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III. Oral Surg Oral Med Oral Pathol Oral Radiol 2016; 121:367–372.
Pichardo SE, Kuijpers SC, van Merkesteyn JP. Bisphosphonate-related osteonecrosis of the jaws: cohort study of surgical treatment results in seventy-four stage II/III patients. J Craniomaxillofac Surg 2016; 44:1216–1220.
Carlson ER. Management of antiresorptive osteonecrosis of the jaws with primary surgical resection. J Oral Maxillofac Surg 2014; 72:655–657.
Oteri G, De Ponte FS, Runci M, et al. Oral-health-related quality of life after surgical treatment of osteonecrosis of the jaws. J Craniofac Surg 2018; 29:403–408.
Silva LF, Curra C, Munerato MS, et al. Surgical management of bisphosphonate-related osteonecrosis of the jaws: literature review. Oral Maxillofac Surg 2016; 20:9–17.