Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.
Cx3cr1
CreERT2
RNA sequencing
microglia
oxygen-induced retinopathy
retinal neovascularization
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
17
07
2019
revised:
12
02
2020
accepted:
19
02
2020
pubmed:
10
3
2020
medline:
1
12
2021
entrez:
10
3
2020
Statut:
ppublish
Résumé
Myeloid cells such as resident retinal microglia (MG) or infiltrating blood-derived macrophages (Mϕ) accumulate in areas of retinal ischemia and neovascularization (RNV) and modulate neovascular eye disease. Their temporospatial distribution and biological function in this process, however, remain unclarified. Using state-of-the-art methods, including cell-specific reporter mice and high-throughput RNA sequencing (RNA Seq), this study determined the extent of MG proliferation and Mϕ infiltration in areas with retinal ischemia and RNV in Cx3cr1
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1859-1873Informations de copyright
© 2020 The Authors. Glia published by Wiley Periodicals, Inc.
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