Sepsis-Associated Encephalopathy: From Delirium to Dementia?
SAE
brain dysfunction
cognitive deficits
delirium
dementia
encephalopathy
long-term sequelae
pathophysiology
sepsis
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
05 Mar 2020
05 Mar 2020
Historique:
received:
29
01
2020
revised:
20
02
2020
accepted:
03
03
2020
entrez:
11
3
2020
pubmed:
11
3
2020
medline:
11
3
2020
Statut:
epublish
Résumé
Sepsis is a major cause of death in intensive care units worldwide. The acute phase of sepsis is often accompanied by sepsis-associated encephalopathy, which is highly associated with increased mortality. Moreover, in the chronic phase, more than 50% of surviving patients suffer from severe and long-term cognitive deficits compromising their daily quality of life and placing an immense burden on primary caregivers. Due to a growing number of sepsis survivors, these long-lasting deficits are increasingly relevant. Despite the high incidence and clinical relevance, the pathomechanisms of acute and chronic stages in sepsis-associated encephalopathy are only incompletely understood, and no specific therapeutic options are yet available. Here, we review the emergence of sepsis-associated encephalopathy from initial clinical presentation to long-term cognitive impairment in sepsis survivors and summarize pathomechanisms potentially contributing to the development of sepsis-associated encephalopathy.
Identifiants
pubmed: 32150970
pii: jcm9030703
doi: 10.3390/jcm9030703
pmc: PMC7141293
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Center for Sepsis Control and Care
ID : ENC-Rescue and GliAct
Organisme : Interdisciplinary Center for Clinical Research Jena University Hospital
ID : Rotational position to HYC and JW
Organisme : Hermann and Lilly Schilling Foundation
ID : to CG
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