Cerebral HSV-1 Vasculitis as a Fatal Complication of Immunosuppression in Non-Hodgkin´s Lymphoma: A Case Report and Review of the Literature.
Non-Hodgkin´s lymphoma
cerebral vasculitis
immunosuppression.
opportunistic infection
splenic marginal cell lymphoma
viral encephalitis
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
05 Mar 2020
05 Mar 2020
Historique:
received:
23
01
2020
revised:
02
03
2020
accepted:
05
03
2020
entrez:
11
3
2020
pubmed:
11
3
2020
medline:
11
3
2020
Statut:
epublish
Résumé
Patients with lymphoma are predisposed to infection because of the immunocompromised state related to the disease itself and as a consequence of chemo-/radiotherapy. Here, we report a case of Herpes-simplex virus encephalitis (HSE) in an immunosuppressed patient with splenic marginal zone lymphoma (SMZL), a rare indolent variant of non-Hodgkin´s lymphoma (NHL). The course was complicated febrile neutropenia and HSV-1-related cerebral vasculitis causing progressive ischemic stroke. This case illustrates the expanding spectrum of atypical clinical and radiological manifestations of HSE in patients treated with myelotoxic drugs. Moreover, we summarize the few central nervous system manifestations of SMZL reported in the literature and discuss distinct causes of neurological deterioration in patients with NHL.
Identifiants
pubmed: 32151046
pii: pathogens9030193
doi: 10.3390/pathogens9030193
pmc: PMC7157652
pii:
doi:
Types de publication
Case Reports
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Expert Rev Hematol. 2017 May;10(5):405-415
pubmed: 28395545
Neurology. 2015 Jun 9;84(23):2377-8
pubmed: 25957334
Front Immunol. 2019 Jul 11;10:1564
pubmed: 31354720
J Neurol. 2017 Jun;264(6):1204-1208
pubmed: 28516331
Am J Hematol. 2017 Aug;92(8):806-813
pubmed: 28699667
Oncology. 2016;91(6):302-310
pubmed: 27682623
J Neuroinflammation. 2019 Jan 29;16(1):19
pubmed: 30696448
Anticancer Res. 2013 Aug;33(8):3263-8
pubmed: 23898089
J Neurol Sci. 2018 Jan 15;384:89-90
pubmed: 29249385
Clin Neuroradiol. 2020 Mar;30(1):9-25
pubmed: 31538219
J Neurovirol. 2020 Feb;26(1):138-141
pubmed: 31468470
Hematol Oncol. 2019 Apr;37(2):219-222
pubmed: 30592785
Neurol Clin Pract. 2014 Jun;4(3):206-215
pubmed: 25110619
Am J Ther. 2014 Sep-Oct;21(5):e137-42
pubmed: 23075577
BMC Cancer. 2016 Mar 17;16:233
pubmed: 26988237
J Clin Oncol. 2008 Sep 20;26(27):4509-11
pubmed: 18802164
Int J Hematol. 2005 Jul;82(1):63-5
pubmed: 16105762
Neurotherapeutics. 2016 Jul;13(3):493-508
pubmed: 27106239
Case Rep Neurol. 2011 Jan 29;3:39-44
pubmed: 21468362
J Virol. 1996 Feb;70(2):898-904
pubmed: 8551629
Mult Scler Relat Disord. 2018 Nov;26:68-70
pubmed: 30227312
Leuk Lymphoma. 2002 Mar;43(3):587-93
pubmed: 12002763
Ann Hematol. 2010 Oct;89(10):1003-9
pubmed: 20440502
Crit Care Med. 2012 Apr;40(4):1304-8
pubmed: 22067626
Med Mal Infect. 2017 May;47(3):221-235
pubmed: 28341533
Expert Rev Neurother. 2016;16(2):205-21
pubmed: 26689107
Rev Bras Hematol Hemoter. 2017 Apr - Jun;39(2):146-154
pubmed: 28577652
J Infect. 2012 Apr;64(4):347-73
pubmed: 22120595
Mult Scler Relat Disord. 2016 Nov;10:134-136
pubmed: 27919480
Best Pract Res Clin Haematol. 2017 Mar - Jun;30(1-2):56-64
pubmed: 28288718
Leuk Lymphoma. 2006 Oct;47(10):2253-6
pubmed: 17071504
Leuk Lymphoma. 2002 Jun;43(6):1337-40
pubmed: 12153005
J Oncol Pharm Pract. 2017 Jan;23(1):33-42
pubmed: 26568602
Neurology. 2012 Nov 20;79(21):2125-32
pubmed: 23136265
Am J Case Rep. 2017 Jun 01;18:611-616
pubmed: 28566677
Clin Lymphoma. 2003 Sep;4(2):93-8
pubmed: 14556680
Ecancermedicalscience. 2018 May 17;12:836
pubmed: 29910833
Viral Immunol. 2019 Dec;32(10):424-429
pubmed: 31599707
Ann Oncol. 2002 Jul;13(7):1099-107
pubmed: 12176790
Int J Infect Dis. 2017 Jun;59:77-81
pubmed: 28435023
Cancer. 1994 Jul 1;74(1):61-5
pubmed: 8004584
J Clin Oncol. 2011 Mar 20;29(9):e234-6
pubmed: 21205746
J Neurooncol. 2016 May;128(1):75-84
pubmed: 26900076
Drug Discov Today. 2019 Jul;24(7):1398-1404
pubmed: 31100209