Evidence for the emergence of an opioid-resistant respiratory rhythm following fentanyl overdose.

Analgesics, Opioid / toxicity Animals Apnea / chemically induced Drug Overdose / physiopathology Fentanyl / toxicity Male Rats Rats, Sprague-Dawley Respiratory Mechanics / drug effects Tidal Volume / drug effects
Breathing depression Opioid overdose

Journal

Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022

Informations de publication

Date de publication:
06 2020
Historique:
received: 01 10 2019
revised: 12 02 2020
accepted: 04 03 2020
pubmed: 11 3 2020
medline: 16 9 2021
entrez: 11 3 2020
Statut: ppublish

Résumé

Breathing resumes within one to two minutes following fentanyl overdose induced apnea in spontaneously breathing rats. As this regular rhythm is produced at a time wherein fentanyl concentrations and receptor occupancy are likely to be extremely high, the mechanisms initiating and sustaining such a respiratory activity remain unclear. Forty-four un-anesthetized adult rats were studied in an open-flow plethysmograph. Regardless of the dose of fentanyl that was used, i.e. 50 μg.kg

Identifiants

DOI: 10.1016/j.resp.2020.103428 PMID: 32151709
pubmed: 32151709
pii: S1569-9048(20)30086-0
doi: 10.1016/j.resp.2020.103428
pii:
doi:

Substances chimiques

Analgesics, Opioid 0
Fentanyl UF599785JZ

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103428

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Philippe Haouzi (P)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USA. Electronic address: phaouzi@pennstatehealth.psu.edu.

Nicholas Mellen (N)

Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.

Marissa McCann (M)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USA. Electronic address: mmccann2@pennstatehealth.psu.edu.

Molly Sternick (M)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USA.

Daniel Guck (D)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USA.

Nicole Tubbs (N)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USA.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › Evidence for the emergence of an...
questionsmedicales.fr › Eucaryotes › Animaux › Evidence for the emergence of an...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Apnée › Evidence for the emergence of an...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Mésusage de médicament › Surdose › Mauvais usage des médicaments prescrits › Evidence for the emergence of an...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Fentanyl › Evidence for the emergence of an...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Evidence for the emergence of an...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Evidence for the emergence of an...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Respiration › Mécanique respiratoire › Evidence for the emergence of an...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Capacité pulmonaire totale › Capacité vitale › Capacité inspiratoire › Volume courant › Evidence for the emergence of an...