Do infections have a role in the pathogenesis of Alzheimer disease?
Journal
Nature reviews. Neurology
ISSN: 1759-4766
Titre abrégé: Nat Rev Neurol
Pays: England
ID NLM: 101500072
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
accepted:
07
02
2020
pubmed:
11
3
2020
medline:
29
4
2020
entrez:
11
3
2020
Statut:
ppublish
Résumé
The idea that infectious agents in the brain have a role in the pathogenesis of Alzheimer disease (AD) was proposed nearly 30 years ago. However, this theory failed to gain substantial traction and was largely disregarded by the AD research community for many years. Several recent discoveries have reignited interest in the infectious theory of AD, culminating in a debate on the topic at the Alzheimer's Association International Conference (AAIC) in July 2019. In this Viewpoint article, experts who participated in the AAIC debate weigh up the evidence for and against the infectious theory of AD and suggest avenues for future research and drug development.
Identifiants
pubmed: 32152461
doi: 10.1038/s41582-020-0323-9
pii: 10.1038/s41582-020-0323-9
doi:
Substances chimiques
Apolipoprotein E4
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-197Commentaires et corrections
Type : CommentIn
Références
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