Viscoelastic haemostatic assays and fibrinogen in paediatric acute traumatic coagulopathy: A comprehensive review.
coagulopathy
fibrinogen
major haemorrhage
paediatric
trauma
viscoelastic haemostatic assay
Journal
Emergency medicine Australasia : EMA
ISSN: 1742-6723
Titre abrégé: Emerg Med Australas
Pays: Australia
ID NLM: 101199824
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
10
09
2019
revised:
05
02
2020
accepted:
05
02
2020
pubmed:
11
3
2020
medline:
19
8
2021
entrez:
11
3
2020
Statut:
ppublish
Résumé
Haemorrhage in paediatric trauma remains a significant cause of morbidity and mortality. Over recent years there has been increasing attention to the role of fibrinogen in traumatic haemorrhage and the association of low fibrinogen levels with poor patient outcomes. In addition, there has been a move towards using viscoelastic haemostatic assays (VHAs) to rapidly assess coagulation status and guide clinicians in the replacement of coagulation factors, including fibrinogen. In the paediatric population, there has been limited uptake of these principles and a paucity of data to support a change in practice. This paper summarises the available evidence in the published literature through a systematic review, presented in narrative format. There is limited high-quality prospective data on the use of VHA in the management of acute traumatic coagulopathy in the paediatric population. While the use of fibrinogen early in major haemorrhage is becoming standard practice, there are currently no randomised prospective studies comparing fibrinogen concentrate to cryoprecipitate. The early identification of hypo-fibrinogenemia and acute traumatic coagulopathy in paediatric trauma using VHA testing and subsequent early fibrinogen replacement with a concentrated off the shelf product is an attractive treatment option. However, there is currently insufficient high-level evidence to support the use of fibrinogen concentrate over cryoprecipitate in the paediatric trauma population. Pilot studies currently under way will go some way to addressing this important knowledge gap, and facilitate the design of larger definitive multi-centre randomised trials.
Identifiants
pubmed: 32153133
doi: 10.1111/1742-6723.13484
doi:
Substances chimiques
Hemostatics
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
313-319Informations de copyright
© 2020 Australasian College for Emergency Medicine.
Références
Centres for Disease Control and Prevention. Faststats - Child Health. [Cited 3 May 2017.] Available from URL: https://www.cdc.gov/nchs/fastats/child-health.htm
World Health Organization. Injuries and Violence: The Facts 2014. Geneva: World Health Organization, 2014.
Patregnani JT, Borgman MA, Maegele M, Wade CE, Blackbourne LH, Spinella PC. Coagulopathy and shock on admission is associated with mortality for children with traumatic injuries at combat support hospitals. Pediatr. Crit. Care Med. 2012; 13: 273-7.
Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J. Trauma Acute Care Surg. 2003; 54: 1127-30.
Hess JR, Brohi K, Dutton RP et al. The coagulopathy of trauma: a review of mechanisms. J. Trauma Acute Care Surg. 2008; 65: 748-54.
Hendrickson JE, Shaz BH, Pereira G et al. Coagulopathy is prevalent and associated with adverse outcomes in transfused pediatric trauma patients. J. Pediatr. 2012; 160: 204-9.e3.
Whittaker B, Christiaans SC, Altice JL et al. Early coagulopathy is an independent predictor of mortality in children after severe trauma. Shock 2013; 39: 421-6.
Christiaans SC, Duhachek-Stapelman AL, Russell RT, Lisco SJ, Kerby JD, Pittet J-F. Coagulopathy after severe pediatric trauma: a review. Shock 2014; 41: 476-90.
Davenport R, Manson J, De'Ath H et al. Functional definition and characterisation of acute traumatic coagulopathy. Crit. Care Med. 2011; 39: 2652.
Haas T, Spielmann N, Mauch J et al. Comparison of thromboelastometry (ROTEM®) with standard plasmatic coagulation testing in paediatric surgery. Br. J. Anaesth. 2011; 108: 36-41.
Chandler WL, Ferrell C, Trimble S, Moody S. Development of a rapid emergency hemorrhage panel. Transfusion 2010; 50: 2547-52.
Vogel AM, Radwan ZA, Cox CS Jr, Cotton BA. Admission rapid thrombelastography delivers real-time "actionable" data in pediatric trauma. J. Pediatr. Surg. 2013; 48: 1371-6.
Nystrup KB, Stensballe J, Bottger M, Johansson PI, Ostrowski SR. Transfusion therapy in paediatric trauma patients: a review of the literature. Scand. J. Trauma Resusc. Emerg. Med. 2015; 23: 21.
Holcomb JB, Del Junco DJ, Fox EE et al. The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg. 2013; 148: 127-36.
Diab YA, Wong ECC, Luban NLC. Massive transfusion in children and neonates. Br. J. Haematol. 2013; 161: 15-26.
Chidester SJ, Williams N, Wang W, Groner JI. A pediatric massive transfusion protocol. J. Trauma Acute Care Surg. 2012; 73: 1273-7.
Hendrickson JE, Shaz BH, Pereira G et al. Implementation of a pediatric trauma massive transfusion protocol: one institution's experience. Transfusion 2012; 52: 1228-36.
Davenport R, Khan S. Management of major trauma haemorrhage: treatment priorities and controversies. Br. J. Haematol. 2011; 155: 537-48.
Winearls J, Reade M, Miles H et al. Targeted coagulation management in severe trauma: the controversies and the evidence. Anesth. Analg. 2016; 123: 910-24.
Romlin BS, Wåhlander H, Berggren H et al. Intraoperative thromboelastometry is associated with reduced transfusion prevalence in pediatric cardiac surgery. Anesth. Analg. 2011; 112: 30-6.
Andreasen JB, Hvas A-M, Christiansen K, Ravn HB. Can ROTEM® analysis be applied for haemostatic monitoring in paediatric congenital heart surgery? Cardiol. Young 2011; 21: 684-91.
Nakayama Y, Nakajima Y, Tanaka KA et al. Thromboelastometry-guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery. Br. J. Anaesth. 2014; 114: 91-102.
Leeper CM, Gaines BA. Viscoelastic hemostatic assays in the management of the pediatric trauma patient. Semin. Pediatr. Surg. 2017; 26: 8-13.
Etchill E, Sperry J, Zuckerbraun B et al. The confusion continues: results from an American Association for the surgery of trauma survey on massive transfusion practices among United States trauma centers. Transfusion 2016; 56: 2478-86.
Russell RT, Maizlin II, Vogel AM. Viscoelastic monitoring in pediatric trauma: a survey of pediatric trauma society members. J. Surg. Res. 2017; 214: 216-20.
Solomon C, Asmis LM, Spahn DR. Is viscoelastic coagulation monitoring with ROTEM or TEG validated? Scand. J. Clin. Lab. Invest. 2016; 76: 503-7.
Hans GA, Besser MW. The place of viscoelastic testing in clinical practice. Br. J. Haematol. 2016; 173: 37-48.
Fries D, Martini W. Role of fibrinogen in trauma-induced coagulopathy. Br. J. Anaesth. 2010; 105: 116-21.
Levy JH, Szlam F, Tanaka KA, Sniecienski RM. Fibrinogen and hemostasis: a primary hemostatic target for the management of acquired bleeding. Anesth. Analg. 2012; 114: 261-74.
Hiippala ST, Myllyla GJ, Vahtera EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth. Analg. 1995; 81: 360-5.
Livingston MH, Singh S, Merritt NH. Massive transfusion in paediatric and adolescent trauma patients: incidence, patient profile, and outcomes prior to a massive transfusion protocol. Injury 2014; 45: 1301-6.
Rourke C, Curry N, Khan S et al. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J. Thromb. Haemost. 2012; 10: 1342-51.
Hagemo JS, Stanworth S, Juffermans NP et al. Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study. Crit. Care 2014; 18: R52.
Rossaint R, Bouillon B, Cerny V et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit. Care 2016; 20: 100.
Bolliger D, Szlam F, Molinaro R, Rahe-Meyer N, Levy J, Tanaka K. Finding the optimal concentration range for fibrinogen replacement after severe haemodilution: an in vitro model. Br. J. Anaesth. 2009; 102: 793-9.
McQuilten ZK, Bailey M, Cameron PA et al. Fibrinogen concentration and use of fibrinogen supplementation with cryoprecipitate in patients with critical bleeding receiving massive transfusion: a bi-national cohort study. Br. J. Haematol. 2017; 179: 131-41.
Holcomb JB, Fox EE, Zhang X et al. Cryoprecipitate use in the prospective observational multicenter major trauma transfusion study (PROMMTT). J. Trauma Acute Care Surg. 2013; 75: S31.
Tanaka KA, Bader SO, Görlinger K. Novel approaches in management of perioperative coagulopathy. Curr. Opin. Anesthesiol. 2014; 27: 72-80.
Schochl H, Cotton B, Inaba K et al. FIBTEM provides early prediction of massive transfusion in trauma. Crit. Care 2011; 15: R265.
Hagemo JS, Christiaans SC, Stanworth SJ et al. Detection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: an international prospective validation study. Crit. Care 2015; 19: 97.
Haas T, Fries D, Velik-Salchner C, Oswald E, Innerhofer P. Fibrinogen in craniosynostosis surgery. Anesth. Analg. 2008; 106: 725-31.
Lunde J, Stensballe J, Wikkelso A, Johansen M, Afshari A. Fibrinogen concentrate for bleeding - a systematic review. Acta Anaesthesiol. Scand. 2014; 58: 1061-74.
Kozek-Langenecker S, Sørensen B, Hess JR, Spahn DR. Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review. Crit. Care 2011; 15: R239.
Collins P, Solomon C, Sutor K et al. Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate. Br. J. Anaesth. 2014; 113: 585-95.
Cannon JW, Johnson MA, Caskey RC, Borgman MA, Neff LP. High ratio plasma resuscitation does not improve survival in pediatric trauma patients. J. Trauma Acute Care Surg. 2017; 83: 211-7.
Karam O, Lacroix J, Robitaille N, Rimensberger P, Tucci M. Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study. Vox Sang. 2013; 104: 342-9.
Stainsby D, MacLennan S, Thomas D, Isaac J, Hamilton P, British Committee for Standards in Haematology. Guidelines on the management of massive blood loss. Br. J. Haematol. 2006; 135: 634-41.
Kozek-Langenecker SA, Afshari A, Albaladejo P et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur. J. Anaesthesiol. 2013; 30: 270-382.
Schöchl H, Nienaber U, Maegele M et al. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Crit. Care 2011; 15: R83.
Ziegler B, Schimke C, Marchet P, Stögermüller B, Schöchl H, Solomon C. Severe pediatric blunt trauma - successful ROTEM-guided hemostatic therapy with fibrinogen concentrate and no administration of fresh frozen plasma or platelets. Clin. Appl. Thromb. Hemost. 2013; 19: 453-9.
Curry N, Rourke C, Davenport R et al. Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial. Br. J. Anaesth. 2015; 115: 76-83.
Solomon C, Gröner A, Jian Y, Inna P. Safety of fibrinogen concentrate: analysis of more than 27 years of pharmacovigilance data. Thromb. Haemost. 2015; 114: 759-71.
Dickneite G, Joch C, Bergman GE. The evaluation of a prothrombotic risk in a human fibrinogen concentrate. Blood (American Society of Hematology Annual Meeting Abstracts). 2008; 112: 4064.
Curry N, Foley C, Wong H et al. Early fibrinogen concentrate therapy for major haemorrhage in trauma (E-FIT 1): results from a UK multi-centre, randomised, double blind, placebo-controlled pilot trial. Crit. Care 2018; 22: 164.
Winearls J, Wullschleger M, Wake E et al. Fibrinogen Early In Severe Trauma studY (FEISTY): study protocol for a randomised controlled trial. Trials 2017; 18: 241.
Nardi G, Agostini V, Rondinelli B et al. Trauma-induced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs. Crit. Care 2015; 19: 83.
Nascimento B, Callum J, Tien H et al. Fibrinogen in the initial resuscitation of severe trauma (FiiRST): a randomized feasibility trial. Br. J. Anaesth. 2016; 117: 775-82.
Fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in children: a pilot randomised controlled trial. [Cited 7 Aug 2018.] Available from URL: https://ClinicalTrials.gov/show/NCT03508141