Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D.

Animals Arthritis, Experimental / immunology Arthritis, Rheumatoid / immunology Complement Factor D / genetics Complement Pathway, Alternative / genetics Complement Pathway, Mannose-Binding Lectin / genetics Gene Expression Lipopolysaccharides / pharmacology Liver / metabolism Mannose-Binding Protein-Associated Serine Proteases / genetics Mice Mice, Inbred C57BL Mice, Knockout RNA Interference RNA, Small Interfering / administration & dosage Signal Transduction / drug effects Transcription, Genetic / genetics Transfection
Factor D MBL-associated serine proteases arthritis complement gene silencing liver

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 11 11 2019
accepted: 27 01 2020
entrez: 11 3 2020
pubmed: 11 3 2020
medline: 20 2 2021
Statut: epublish

Résumé

The complement system plays an important role in the pathogenesis of rheumatoid arthritis (RA). Besides driving lectin pathway (LP) activation, the mannan-binding lectin (MBL)-associated serine proteases (MASPs) also play a key role in regulating the alternative pathway (AP). We evaluated the effects of N-acetylgalactosamine (GalNAc)-conjugated MASP-1 and MASP-2 duplexes

Identifiants

DOI: 10.3389/fimmu.2020.00201 PMID: 32153567 PMC: PMC7046807
pubmed: 32153567
doi: 10.3389/fimmu.2020.00201
pmc: PMC7046807
doi:

Substances chimiques

Lipopolysaccharides 0
RNA, Small Interfering 0
MASP-1 protein, mouse EC 3.4.21.-
MASP-2 protein, mouse EC 3.4.21.-
Mannose-Binding Protein-Associated Serine Proteases EC 3.4.21.-
Complement Factor D EC 3.4.21.46

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

201

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR051749
Pays : United States

Informations de copyright

Copyright © 2020 Holers, Borodovsky, Scheinman, Ho, Ramirez, Dobó, Gál, Lindenberger, Hansen, Desai, Pihl, Thiel and Banda.

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Auteurs

V Michael Holers (VM)

Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Anna Borodovsky (A)

Alnylam Pharmaceutical Inc., Boston, MA, United States.

Robert I Scheinman (RI)

Skaggs School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Nhu Ho (N)

Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Joseline Ramos Ramirez (JR)

Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

József Dobó (J)

Research Centre for Natural Sciences, Institute of Enzymology, Budapest, Hungary.

Péter Gál (P)

Research Centre for Natural Sciences, Institute of Enzymology, Budapest, Hungary.

Jared Lindenberger (J)

Department of Biochemistry and Molecular Genetics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States.

Annette G Hansen (AG)

Department of Biomedicine, University of Aarhus, Aarhus, Denmark.

Dhruv Desai (D)

Alnylam Pharmaceutical Inc., Boston, MA, United States.

Rasmus Pihl (R)

Department of Biomedicine, University of Aarhus, Aarhus, Denmark.

Steffen Thiel (S)

Department of Biomedicine, University of Aarhus, Aarhus, Denmark.

Nirmal K Banda (NK)

Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Key Components of the Complement Lectin...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Arthrite expérimentale › Key Components of the Complement Lectin...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Key Components of the Complement Lectin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Enzymes activatrices du complément › Facteur D du complément › Key Components of the Complement Lectin...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation du complément › Voie alterne d'activation du complément › Key Components of the Complement Lectin...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation du complément › Voie des lectines › Key Components of the Complement Lectin...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Key Components of the Complement Lectin...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Key Components of the Complement Lectin...
questionsmedicales.fr › Système digestif › Foie › Key Components of the Complement Lectin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Enzymes activatrices du complément › Complement C3-C5 Convertases › Mannose-Binding Protein-Associated Serine Proteases › Key Components of the Complement Lectin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Key Components of the Complement Lectin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Key Components of the Complement Lectin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Key Components of the Complement Lectin...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Interférence par ARN › Key Components of the Complement Lectin...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Key Components of the Complement Lectin...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Key Components of the Complement Lectin...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Key Components of the Complement Lectin...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Transfection › Key Components of the Complement Lectin...