The Role of Promyelocytic Leukemia Nuclear Bodies During HPV Infection.
HPV—human papillomavirus
Innate immnuity
L2 protein
PML
PML nuclear bodies
infectious entry
transcription
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
11
2019
accepted:
17
01
2020
entrez:
11
3
2020
pubmed:
11
3
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Promyelocytic leukemia (PML) nuclear bodies (NBs) are highly dynamic subnuclear structures. Their name giving major component, PML protein, is essential for their formation. PML is present in many different isoforms due to differential splicing, which seem to contribute differently to PML NBs function. Sp100 and DAXX are also permanently residing in these structures. PML NBs disassemble in mitosis to form large cytoplasmic aggregates and reassemble after completion of cell division. Posttranslational modifications such as SUMOylation play important roles for protein association with PML NBs. In addition to the factors permanently associated with PML NBs, a large number of proteins may transiently reside in PML NBs dependent on cell stage, type, and condition. PML NBs have been indirectly implicated in a large number of cellular processes including apoptosis, transcriptional regulation, DNA repair and replication. They are considered hot spots for posttranslational modifications and may serve as readily accessible protein depots. However, a precise function has been difficult to assign. Many DNA viruses target PML NBs after entry often resulting in reorganization of these subnuclear structures. Antiviral activity has been assigned to PML NBs partially based on the observation that PML protein is an interferon stimulated gene. In contrast, human papillomavirus (HPV) infection requires the presence of PML protein suggesting that PML NBs may be essential to establish infection. This review will summarize and discuss recent advances in our understanding of the role of PML NBs and individual protein components in the establishment of HPV infection.
Identifiants
pubmed: 32154186
doi: 10.3389/fcimb.2020.00035
pmc: PMC7045071
doi:
Substances chimiques
Nuclear Proteins
0
Promyelocytic Leukemia Protein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
35Subventions
Organisme : NIGMS NIH HHS
ID : P30 GM110703
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI081809
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI132149
Pays : United States
Informations de copyright
Copyright © 2020 Guion and Sapp.
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