The mRNA-Binding Protein IGF2BP1 Restores Fetal Hemoglobin in Cultured Erythroid Cells from Patients with β-Hemoglobin Disorders.
IGF2BP1
beta-thalassemia
fetal hemoglobin
gene regulation
gene therapy
hemoglobinopathies
lentivirus
sickle cell disease
Journal
Molecular therapy. Methods & clinical development
ISSN: 2329-0501
Titre abrégé: Mol Ther Methods Clin Dev
Pays: United States
ID NLM: 101624857
Informations de publication
Date de publication:
12 Jun 2020
12 Jun 2020
Historique:
received:
13
08
2019
accepted:
22
01
2020
entrez:
11
3
2020
pubmed:
11
3
2020
medline:
11
3
2020
Statut:
epublish
Résumé
Sickle cell disease (SCD) and β-thalassemia are caused by structural abnormality or inadequate production of adult hemoglobin (HbA, α
Identifiants
pubmed: 32154328
doi: 10.1016/j.omtm.2020.01.011
pii: S2329-0501(20)30022-X
pmc: PMC7056608
doi:
Types de publication
Journal Article
Langues
eng
Pagination
429-440Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL053749
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025674
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK106857
Pays : United States
Informations de copyright
© 2020 The Author(s).
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