Bilaminar Structure of the Human Optic Nerve Sheath.
Biomechanics
elastin
optic nerve dura
optic nerve sheath
Journal
Current eye research
ISSN: 1460-2202
Titre abrégé: Curr Eye Res
Pays: England
ID NLM: 8104312
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
11
3
2020
medline:
6
8
2021
entrez:
11
3
2020
Statut:
ppublish
Résumé
We aimed to characterize the connective tissue microanatomy, elastin abundance, and fiber orientation in the human optic nerve sheath, also known as the optic nerve dura mater, for correlation with its biomechanical properties. Seven whole human orbits aged 4-93 years, and five isolated human optic nerve sheaths aged 26-75 years were formalin fixed, paraffin embedded, coronally sectioned, stained by Masson trichrome and van Gieson's elastin methods, and analyzed quantitatively for elastin fiber abundance and orientation. Elastin area fraction was defined as area stained for elastin divided by total area. While unilaminar in children, the adult ON sheath exhibited distinct inner and outer layers. Collagen was denser and more compact in the inner layer. Elastin area fraction was significantly greater at 6.0 ± 0.4% (standard error of mean) in the inner than outer layer at 3.6 ± 0.4% ( The adult human optic nerve sheath is bilaminar, with each layer containing elastin fibers oriented in multiple directions consistent with isotropic properties. Differences in laminar elastin density and orientation may reflect greater tensile loading in the inner than in the outer layer.
Identifiants
pubmed: 32155090
doi: 10.1080/02713683.2020.1739314
pmc: PMC7286776
mid: NIHMS1579222
doi:
Substances chimiques
Elastin
9007-58-3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
864-872Subventions
Organisme : NEI NIH HHS
ID : P30 EY000331
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY008313
Pays : United States
Organisme : NEI NIH HHS
ID : T32 EY007026
Pays : United States
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