Stress Erythropoiesis is a Key Inflammatory Response.
anemia of inflammation
erythroblastic islands
erythrophagocytosis
pro-inflammatory cytokines
stress erythropoiesis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
06 03 2020
06 03 2020
Historique:
received:
09
02
2020
revised:
27
02
2020
accepted:
03
03
2020
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
12
3
2021
Statut:
epublish
Résumé
Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen. Despite the enormous capacity of the bone marrow to produce erythrocytes, there are times when it is unable to keep pace with erythroid demand. At these times stress erythropoiesis predominates. Stress erythropoiesis generates a large bolus of new erythrocytes to maintain homeostasis until steady state erythropoiesis can resume. In this review, we outline the mechanistic differences between stress erythropoiesis and steady state erythropoiesis and show that their responses to inflammation are complementary. We propose a new hypothesis that stress erythropoiesis is induced by inflammation and plays a key role in maintaining erythroid homeostasis during inflammatory responses.
Identifiants
pubmed: 32155728
pii: cells9030634
doi: 10.3390/cells9030634
pmc: PMC7140438
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK119865
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK080040
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146528
Pays : United States
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