Metformin effect on gut microbiota: insights for HIV-related inflammation.
Gut permeability
HIV
Inflammation
Metformin
Microbiota
Journal
AIDS research and therapy
ISSN: 1742-6405
Titre abrégé: AIDS Res Ther
Pays: England
ID NLM: 101237921
Informations de publication
Date de publication:
10 03 2020
10 03 2020
Historique:
received:
20
11
2019
accepted:
24
02
2020
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
13
1
2021
Statut:
epublish
Résumé
The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in the clinical outcome of diabetes, inflammatory bowel diseases, cancer, aging and HIV infection. Gut dysbiosis and inflammation persist in people living with HIV (PLWH) despite receiving antiretroviral therapy, further contributing to non-AIDS comorbidities. Metformin, a widely used antidiabetic agent, has been found to benefit microbiota composition, promote gut barrier integrity and reduce inflammation in human and animal models of diabetes. Inspired by the effect of metformin on diabetes-related gut dysbiosis, we herein critically review the relevance of metformin to control inflammation in PLWH. Metformin may improve gut microbiota composition, in turn reducing inflammation and risk of non-AIDS comorbidities. This review will pave the way towards innovative strategies to counteract dysregulated microbiota and improve the lives of PLWH.
Identifiants
pubmed: 32156291
doi: 10.1186/s12981-020-00267-2
pii: 10.1186/s12981-020-00267-2
pmc: PMC7063824
doi:
Substances chimiques
Metformin
9100L32L2N
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
10Subventions
Organisme : CIHR
ID : HOP 103230
Pays : Canada
Organisme : CIHR
ID : PTJ 166049
Pays : Canada
Organisme : CTN
ID : CTN 257
Pays : International
Organisme : CTN
ID : CTN PT027
Pays : International
Organisme : CANFAR
ID : 02-512
Pays : International
Organisme : CanCURE
ID : HB2-164064
Pays : International
Organisme : Chinese National Science and Technology Major Project
ID : 2018ZX10302104
Pays : International
Références
Nature. 2009 Jul 2;460(7251):108-12
pubmed: 19543266
ISME J. 2018 Aug;12(8):1964-1976
pubmed: 29789624
J Gastroenterol Hepatol. 2014 Mar;29(3):502-10
pubmed: 24716225
PLoS One. 2013 Oct 16;8(10):e78146
pubmed: 24147117
Front Physiol. 2018 Jun 25;9:775
pubmed: 29988585
Nat Med. 2006 Dec;12(12):1365-71
pubmed: 17115046
JAMA. 2019 Sep 19;:1-11
pubmed: 31536102
PLoS One. 2015 Sep 11;10(9):e0135858
pubmed: 26360050
Nat Rev Clin Oncol. 2017 Feb;14(2):85-99
pubmed: 27502359
Adv Immunol. 2014;121:91-119
pubmed: 24388214
PLoS Pathog. 2010 Aug 19;6(8):e1001052
pubmed: 20808901
Microbiome. 2019 May 11;7(1):73
pubmed: 31078141
JAMA. 2014 Jun 11;311(22):2288-96
pubmed: 24915260
Diabetes. 2008 Jun;57(6):1470-81
pubmed: 18305141
Nat Med. 2019 Jul;25(7):1096-1103
pubmed: 31263284
JAMA Oncol. 2019 Sep 5;:e192553
pubmed: 31486833
Gut. 2016 Mar;65(3):426-36
pubmed: 26100928
Ann Pharmacother. 2001 Jul-Aug;35(7-8):877-80
pubmed: 11485138
Nat Commun. 2013;4:2192
pubmed: 23900241
Gastroenterology. 2012 Oct;143(4):913-6.e7
pubmed: 22728514
Diabetes Care. 2017 Jan;40(1):54-62
pubmed: 27999002
J Infect Dis. 2017 Dec 19;216(12):1525-1533
pubmed: 29253205
Am J Transl Res. 2019 Apr 15;11(4):2393-2402
pubmed: 31105845
Dig Dis Sci. 2012 Dec;57(12):3126-35
pubmed: 22684624
Physiology (Bethesda). 2016 Jul;31(4):283-93
pubmed: 27252163
Rev Invest Clin. 2015 Jul-Aug;67(4):273-4
pubmed: 26426594
Sci Transl Med. 2013 Jul 10;5(193):193ra91
pubmed: 23843452
Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24819-24829
pubmed: 31740620
Nat Med. 2018 Dec;24(12):1919-1929
pubmed: 30397356
Gut. 2014 May;63(5):727-35
pubmed: 23804561
Cell Metab. 2017 Oct 3;26(4):611-619.e6
pubmed: 28978426
Diabetologia. 2019 Jun;62(6):1024-1035
pubmed: 30904939
Hamostaseologie. 2015;35(2):128-36
pubmed: 25599530
Appl Environ Microbiol. 2015 Jun;81(11):3655-62
pubmed: 25795669
Nature. 2015 Dec 10;528(7581):262-266
pubmed: 26633628
BMC Infect Dis. 2017 Jun 23;17(1):445
pubmed: 28645263
PLoS One. 2013 May 21;8(5):e63983
pubmed: 23704966
Clin Infect Dis. 2019 Apr 8;68(8):1274-1281
pubmed: 30107503
World J Gastroenterol. 2007 May 28;13(20):2826-32
pubmed: 17569118
Front Immunol. 2020 Jan 17;10:2999
pubmed: 32010125
Gut. 2004 Jan;53(1):1-4
pubmed: 14684564
J Clin Biochem Nutr. 2019 May;64(3):231-238
pubmed: 31138957
J Acquir Immune Defic Syndr. 2016 Feb 1;71(2):130-6
pubmed: 26413854
BMJ Open. 2019 Apr 20;9(4):e028444
pubmed: 31005944
Viruses. 2019 Feb 27;11(3):
pubmed: 30818749
Curr Med Res Opin. 2016 Jul;32(7):1243-52
pubmed: 26986190
J Clin Invest. 2013 Feb;123(2):903-7
pubmed: 23321668
Curr HIV/AIDS Rep. 2019 Jun;16(3):204-213
pubmed: 31037552
AIDS Rev. 2015 Apr-Jun;17(2):96-106
pubmed: 26035167
Atherosclerosis. 2015 Sep;242(1):167-73
pubmed: 26188541
AIDS. 2004 Feb 20;18(3):465-73
pubmed: 15090799
AIDS. 2012 Mar 13;26(5):587-97
pubmed: 22112605
Cell Metab. 2016 Jan 12;23(1):10-2
pubmed: 26771114
J Med Primatol. 2015 Oct;44(5):241-52
pubmed: 26275157
Nature. 2012 Oct 4;490(7418):55-60
pubmed: 23023125
BMC Infect Dis. 2019 Mar 7;19(1):234
pubmed: 30845929
Gut. 2018 Sep;67(9):1716-1725
pubmed: 29934437
EBioMedicine. 2020 Jan;51:102590
pubmed: 31901868
Front Immunol. 2019 Mar 08;10:426
pubmed: 30906299
EBioMedicine. 2018 Dec;38:17-18
pubmed: 30448227
AIDS. 2007 Jan 2;21(1):47-57
pubmed: 17148967
Cell Metab. 2010 May 5;11(5):390-401
pubmed: 20444419
Diabetes Res Clin Pract. 2014 Mar;103(3):e34-6
pubmed: 24485344
Gut. 2018 Jul 31;:
pubmed: 30064988
EBioMedicine. 2018 Nov;37:392-400
pubmed: 30366816
J Allergy Clin Immunol. 2005 Aug;116(2):419-22
pubmed: 16083799
Diabetologia. 2017 Sep;60(9):1662-1667
pubmed: 28770326
Appl Environ Microbiol. 2014 Oct;80(19):5935-43
pubmed: 25038099
Clin Infect Dis. 2020 Jan 2;70(2):232-241
pubmed: 30877304
Mucosal Immunol. 2008 Jan;1(1):23-30
pubmed: 19079157
JAMA. 2000 Jul 26;284(4):472-7
pubmed: 10904511
Sci Rep. 2018 Apr 30;8(1):6725
pubmed: 29712976
Nat Med. 2017 Jul;23(7):850-858
pubmed: 28530702
Science. 2018 Jan 5;359(6371):91-97
pubmed: 29097494
Drugs. 2016 Apr;76(5):533-49
pubmed: 26915027
J Infect Dis. 2019 Jan 9;219(3):497-508
pubmed: 30202890
Cell. 2019 Sep 5;178(6):1299-1312.e29
pubmed: 31474368
PLoS One. 2016 Dec 21;11(12):e0168670
pubmed: 28002460
Brain Behav Immun. 2014 Aug;40:131-42
pubmed: 24632338
PLoS One. 2019 May 29;14(5):e0216948
pubmed: 31141540
Biochem Biophys Res Commun. 2017 Jun 17;488(1):29-32
pubmed: 28478038
Clin Infect Dis. 2003 Jul 15;37(2):315-6
pubmed: 12856228
Clin Infect Dis. 2019 Oct 14;:
pubmed: 31608409
Nat Rev Endocrinol. 2019 Oct;15(10):569-589
pubmed: 31439934
J Lifestyle Med. 2018 Jan;8(1):1-7
pubmed: 29581954
Front Microbiol. 2018 Aug 24;9:1995
pubmed: 30197637
PLoS One. 2010 Feb 05;5(2):e9085
pubmed: 20140211
PLoS One. 2018 Sep 27;13(9):e0204317
pubmed: 30261008
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71
pubmed: 23671105
Diabet Med. 1992 Jan-Feb;9(1):61-5
pubmed: 1551312
AIDS Res Hum Retroviruses. 2020 Jan 8;:
pubmed: 31731885
J Intensive Care Med. 2018 Aug 21;:885066618793385
pubmed: 30126348
Nature. 2013 Jun 6;498(7452):99-103
pubmed: 23719380
Diabetologia. 2008 Aug;51(8):1552-3
pubmed: 18528677
N Engl J Med. 2013 Apr 25;368(17):1575-84
pubmed: 23614584
Nutrients. 2011 Oct;3(10):858-76
pubmed: 22254083
AIDS. 2017 Feb 20;31(4):511-521
pubmed: 28002063