Structural and mechanistic insights into secretagogin-mediated exocytosis.

Animals Binding Sites Brain / growth & development Calcium / metabolism Cell Line Cell Membrane / metabolism Exocytosis Gene Expression Regulation, Developmental Humans Mutation Protein Binding Protein Conformation Secretagogins / chemistry Synaptosomal-Associated Protein 25 / genetics Zebrafish
SNAP-25 SNARE neurological disorder neuronal development regulated exocytosis

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
24 03 2020
Historique:
pubmed: 12 3 2020
medline: 11 8 2020
entrez: 12 3 2020
Statut: ppublish

Résumé

Secretagogin (SCGN) is a hexa-EF-hand protein that is highly expressed in the pancreas, brain, and gastrointestinal tract. SCGN is known to modulate regulated exocytosis in multiple cell lines and tissues; however, its exact functions and underlying mechanisms remain unclear. Here, we report that SCGN interacts with the plasma membrane SNARE SNAP-25, but not the assembled SNARE complex, in a Ca

Identifiants

DOI: 10.1073/pnas.1919698117 PMID: 32156735 PMC: PMC7104245
pubmed: 32156735
pii: 1919698117
doi: 10.1073/pnas.1919698117
pmc: PMC7104245
doi:

Substances chimiques

Secretagogins 0
Synaptosomal-Associated Protein 25 0
Calcium SY7Q814VUP

Banques de données

PDB
['6JLH']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6559-6570

Subventions

Organisme : NICHD NIH HHS
ID : K12 HD068369
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS097333
Pays : United States

Commentaires et corrections

Type : CommentIn

Déclaration de conflit d'intérêts

The authors declare no competing interest.

Références

World J Biol Psychiatry. 2013 Sep;14(7):478-89
pubmed: 22248022
Front Mol Neurosci. 2012 Aug 06;5:84
pubmed: 22888312
Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):61-9
pubmed: 18094468
J Coll Physicians Surg Pak. 2017 Apr;27(4):222-226
pubmed: 28492151
Annu Rev Cell Dev Biol. 2012;28:279-308
pubmed: 23057743
Elife. 2019 Oct 30;8:
pubmed: 31663849
J Neurochem. 2016 Sep;138(6):785-805
pubmed: 27333343
Nat Protoc. 2013 Nov;8(11):2281-2308
pubmed: 24157548
Biochem J. 2007 Jan 1;401(1):353-63
pubmed: 16939418
Mol Biol Cell. 2009 Dec;20(23):4962-75
pubmed: 19812250
Neuron. 2014 Oct 22;84(2):416-31
pubmed: 25374362
Brain Struct Funct. 2019 Jul;224(6):2061-2078
pubmed: 31144035
Neurosci Lett. 1996 Sep 27;216(2):109-12
pubmed: 8904795
J Biol Chem. 2000 Aug 11;275(32):24740-51
pubmed: 10811645
Annu Rev Biophys. 2018 May 20;47:469-497
pubmed: 29792815
EMBO J. 1999 Aug 16;18(16):4372-82
pubmed: 10449403
Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):240-55
pubmed: 15299926
Science. 2014 May 30;344(6187):1023-8
pubmed: 24876496
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1446-E1454
pubmed: 29386389
PLoS Genet. 2007 May 25;3(5):e78
pubmed: 17530925
Science. 2015 Sep 4;349(6252):1111-4
pubmed: 26339030
Nat Commun. 2019 Sep 23;10(1):4326
pubmed: 31548544
PLoS One. 2015 Jul 13;10(7):e0132636
pubmed: 26167908
Nat Protoc. 2017 Sep;12(9):2014-2028
pubmed: 28858288
Signal Transduct Target Ther. 2017 Jun 30;2:17030
pubmed: 29263922
Cell. 1993 Nov 5;75(3):409-18
pubmed: 8221884
Nat Neurosci. 2003 Oct;6(10):1023-30
pubmed: 12973353
Science. 2013 Jan 25;339(6118):421-5
pubmed: 23258414
Nat Neurosci. 2010 Mar;13(3):338-43
pubmed: 20118925
EMBO J. 2017 Jul 14;36(14):2107-2125
pubmed: 28637794
Mol Biol Cell. 2012 Jun;23(12):2352-61
pubmed: 22513087
Cell. 1996 Apr 5;85(1):83-94
pubmed: 8620540
Nat Commun. 2016 Nov 09;7:13305
pubmed: 27827364
Nat Cell Biol. 2011 Jan;13(1):30-9
pubmed: 21151134
Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22598-22608
pubmed: 31624125
PLoS Genet. 2012;8(8):e1002936
pubmed: 22952455
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
Neuroscience. 2019 Nov 10;420:50-71
pubmed: 30267828
Elife. 2019 Jan 18;8:
pubmed: 30657450
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E2006-E2015
pubmed: 28223495
J Biol Chem. 2014 Apr 4;289(14):9639-50
pubmed: 24532794
Nature. 2015 Mar 12;519(7542):223-8
pubmed: 25533962
J Biol Chem. 1995 Mar 24;270(12):6773-8
pubmed: 7896823
EMBO J. 2015 Jan 2;34(1):36-54
pubmed: 25430741
Proteins. 2009 Aug 1;76(2):477-83
pubmed: 19241471
Biochem J. 2016 Jun 15;473(12):1791-803
pubmed: 27095850
Nature. 1998 Sep 24;395(6700):347-53
pubmed: 9759724
Dev Biol. 2012 May 1;365(1):290-302
pubmed: 22426004
Protein Sci. 2018 Aug;27(8):1364-1391
pubmed: 29893445
Nat Med. 2005 Jan;11(1):90-4
pubmed: 15619630
Cell. 1997 Aug 8;90(3):523-35
pubmed: 9267032
Elife. 2017 May 06;6:
pubmed: 28477408
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E922-31
pubmed: 26839408
Trends Endocrinol Metab. 2019 Apr;30(4):234-243
pubmed: 30772140
Nat Struct Biol. 1998 Sep;5(9):765-9
pubmed: 9731768
Mol Biosyst. 2011 Jul;7(7):2196-204
pubmed: 21528130
Nature. 2000 Mar 23;404(6776):355-62
pubmed: 10746715

Auteurs

Jiao Qin (J)

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.

Qi Liu (Q)

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.

Zhe Liu (Z)

Department of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041 Chengdu, China.

Yun-Zu Pan (YZ)

Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Luis Sifuentes-Dominguez (L)

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Karolina P Stepien (KP)

Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Yan Wang (Y)

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.

Yingfeng Tu (Y)

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.

Shuai Tan (S)

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.

Yuan Wang (Y)

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.

Qingxiang Sun (Q)

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.

Xianming Mo (X)

Department of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041 Chengdu, China.

Josep Rizo (J)

Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Ezra Burstein (E)

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Da Jia (D)

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China; jiada@scu.edu.cn.
ORCID: 0000-0002-2205-1998

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Structural and mechanistic insights into...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Structural and mechanistic insights into...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Structural and mechanistic insights into...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Structural and mechanistic insights into...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Structural and mechanistic insights into...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structural and mechanistic insights into...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › Structural and mechanistic insights into...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Structural and mechanistic insights into...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural and mechanistic insights into...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Structural and mechanistic insights into...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structural and mechanistic insights into...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structural and mechanistic insights into...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Secretagogins › Structural and mechanistic insights into...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Protéines SNARE › Protéines Q-SNARE › Protéines Qc-SNARE › Protéine SNAP-25 › Structural and mechanistic insights into...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Structural and mechanistic insights into...