Blockade of β-Catenin-Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration.

Adenocarcinoma / immunology Animals Chemokines, CC / immunology Disease Progression Gene Expression Regulation, Neoplastic / physiology Humans Lymphocytes, Tumor-Infiltrating / immunology Mice Stomach Neoplasms / immunology T-Lymphocytes, Regulatory / immunology Tumor Escape / physiology Tumor Microenvironment / immunology beta Catenin / immunology

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
15 05 2020
Historique:
received: 02 10 2019
revised: 07 01 2020
accepted: 05 03 2020
pubmed: 12 3 2020
medline: 27 10 2020
entrez: 12 3 2020
Statut: ppublish

Résumé

Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However, it remains unclear how β-catenin signaling regulates the tumor immune microenvironment in the stomach. Here, we identify CCL28 as a direct transcriptional target gene of β-catenin/T-cell factor (TCF). Protein levels of β-catenin and CCL28 positively correlated in human gastric adenocarcinoma. β-Catenin-activated CCL28 recruited regulatory T (Treg) cells in a transwell migration assay. In a clinically relevant mouse gastric cancer model established by

Identifiants

DOI: 10.1158/0008-5472.CAN-19-3074 PMID: 32156780
pubmed: 32156780
pii: 0008-5472.CAN-19-3074
doi: 10.1158/0008-5472.CAN-19-3074
doi:

Substances chimiques

CCL28 protein, human 0
Chemokines, CC 0
beta Catenin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2004-2016

Informations de copyright

©2020 American Association for Cancer Research.

Auteurs

Lu Ji (L)

State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, Renji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China.

Wei Qian (W)

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Liming Gui (L)

State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, Renji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China.

Zhongzhong Ji (Z)

State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, Renji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China.

Pan Yin (P)

State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, Renji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China.

Guan Ning Lin (GN)

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

You Wang (Y)

Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Bin Ma (B)

State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, Renji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. gao.weiqiang@sjtu.edu.cn binma@sjtu.edu.cn.
Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China.

Wei-Qiang Gao (WQ)

State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, Renji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. gao.weiqiang@sjtu.edu.cn binma@sjtu.edu.cn.
Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › Eucaryotes › Animaux › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CC › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes TIL › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Tumeurs de l'estomac › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › Phénomènes du système immunitaire › Échappement de la tumeur à la surveillance immunitaire › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Blockade of β-Catenin-Induced CCL28 Suppresses...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › bêta-Caténine › Blockade of β-Catenin-Induced CCL28 Suppresses...