Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.
Broadly Neutralizing Antibodies
/ immunology
Cohort Studies
Epitopes
/ immunology
Female
Genetic Variation
HIV Antibodies
/ immunology
HIV Envelope Protein gp120
/ genetics
HIV Infections
/ immunology
HIV-1
/ genetics
Humans
Infant
Infectious Disease Transmission, Vertical
Malawi
Neutralization Tests
Peptide Fragments
/ genetics
Pregnancy
Pregnancy Complications, Infectious
/ immunology
HIV
MTCT
antibody
bNAbs
infant-T/F virus
mother-to-child transmission
neutralization
vertical transmission
virus
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
10 03 2020
10 03 2020
Historique:
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
12
3
2021
Statut:
epublish
Résumé
Each year, >180,000 infants become infected via mother-to-child transmission (MTCT) of HIV despite the availability of effective maternal antiretroviral treatments, underlining the need for a maternal HIV vaccine. We characterized 224 maternal HIV envelope (Env)-specific IgG monoclonal antibodies (MAbs) from seven nontransmitting and transmitting HIV-infected U.S. and Malawian mothers and examined their neutralization activities against nontransmitted autologous circulating viruses and infant-transmitted founder (infant-T/F) viruses. Only a small subset of maternal viruses, 3 of 72 (4%), were weakly neutralized by maternal linear V3 epitope-specific IgG MAbs, whereas 6 out of 6 (100%) infant-T/F viruses were neutralization resistant to these V3-specific IgG MAbs. We also show that maternal-plasma broadly neutralizing antibody (bNAb) responses targeting the V3 glycan supersite in a transmitting woman may have selected for an N332 V3 glycan neutralization-resistant infant-T/F virus. These data have important implications for bNAb-eliciting vaccines and passively administered bNAbs in the setting of MTCT.
Identifiants
pubmed: 32156815
pii: mBio.00176-20
doi: 10.1128/mBio.00176-20
pmc: PMC7064758
pii:
doi:
Substances chimiques
Broadly Neutralizing Antibodies
0
Epitopes
0
HIV Antibodies
0
HIV Envelope Protein gp120
0
HIV envelope protein gp120 (305-321)
0
Peptide Fragments
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : F31 AI127303
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI068632
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI100645
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI122909
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI106380
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI117915
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131251
Pays : United States
Organisme : NICHD NIH HHS
ID : DP2 HD075699
Pays : United States
Informations de copyright
Copyright © 2020 Martinez et al.
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