Hypergravity induced disruption of cerebellar motor coordination.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 03 2020
10 03 2020
Historique:
received:
18
07
2019
accepted:
21
02
2020
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
24
11
2020
Statut:
epublish
Résumé
The cerebellum coordinates voluntary movements for balanced motor activity in a normal gravity condition. It remains unknown how hypergravity is associated with cerebellum-dependent motor behaviors and Purkinje cell's activities. In order to investigate the relationship between gravity and cerebellar physiology, we measured AMPA-mediated fast currents and mGluR1-mediated slow currents of cerebellar Purkinje cells along with cerebellum-dependent behaviors such as the footprint and irregular ladder under a hypergravity condition. We found abnormal animal behaviors in the footprint and irregular ladder tests under hypergravity. They are correlated with decreased AMPA and mGluR1-mediated synaptic currents of Purkinje cells. These results indicate that gravity regulates the activity of Purkinje cells, thereby modulating cerebellum-dependent motor outputs.
Identifiants
pubmed: 32157179
doi: 10.1038/s41598-020-61453-w
pii: 10.1038/s41598-020-61453-w
pmc: PMC7064588
doi:
Substances chimiques
Receptors, Metabotropic Glutamate
0
metabotropic glutamate receptor type 1
0
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
77521-29-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4452Références
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