Mode of silver clearance following 28-day inhalation exposure to silver nanoparticles determined from lung burden assessment including post-exposure observation periods.
Lung burden
Lung clearance
Silver nanoparticles
Subacute inhalation
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
07
11
2019
accepted:
03
02
2020
pubmed:
12
3
2020
medline:
11
3
2021
entrez:
12
3
2020
Statut:
ppublish
Résumé
Recently revised OECD inhalation toxicity testing guidelines require measurements of lung burden immediately after and for periods following exposure for nanomaterials. Lung burden is a function of pulmonary deposition and retention of nanoparticles. Using lung burden studies as per OECD guidelines, it may be possible to assess clearance mechanisms of nanoparticles. In this study, male rats were exposed to silver nanoparticle (AgNP) aerosols (18.1-19.6 nm) generated from a spark generator. Exposure groups consisted of (1) control (fresh air), (2) low (31.2 ± 8.5 µg/m
Identifiants
pubmed: 32157349
doi: 10.1007/s00204-020-02660-2
pii: 10.1007/s00204-020-02660-2
doi:
Substances chimiques
Aerosols
0
Silver
3M4G523W1G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM