Extracellular nucleic acid scavenging rescues rats from sulfur mustard analog-induced lung injury and mortality.
ARDS
Acute lung injury
Extracellular nucleic acids
Sulfur mustard
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
24
01
2020
accepted:
02
03
2020
pubmed:
12
3
2020
medline:
9
3
2021
entrez:
12
3
2020
Statut:
ppublish
Résumé
Sulfur mustard (SM) is a highly toxic war chemical that causes significant morbidity and mortality and lacks any effective therapy. Rats exposed to aerosolized CEES (2-chloroethyl ethyl sulfide; 10% in ethanol), an analog of SM, developed acute respiratory distress syndrome (ARDS), which is characterized by increased inflammation, hypoxemia and impaired gas exchange. We observed elevated levels of extracellular nucleic acids (eNA) in the bronchoalveolar lavage fluid (BALF) of CEES-exposed animals. eNA can induce inflammation, coagulation and barrier dysfunction. Treatment with hexadimethrine bromide (HDMBr; 10 mg/kg), an eNA neutralizing agent, 2 h post-exposure, reduced lung injury, inhibited disruption of alveolar-capillary barrier, improved blood oxygenation (PaO
Identifiants
pubmed: 32157350
doi: 10.1007/s00204-020-02699-1
pii: 10.1007/s00204-020-02699-1
pmc: PMC7230031
mid: NIHMS1574488
doi:
Substances chimiques
Chemical Warfare Agents
0
Nucleic Acids
0
2-chloroethyl ethyl sulfide
693-07-2
Mustard Gas
T8KEC9FH9P
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1321-1334Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL114933
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES025069
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES028182
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01ES028182
Pays : United States
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