The role of integrins in melanoma: a review.
Journal
International journal of dermatology
ISSN: 1365-4632
Titre abrégé: Int J Dermatol
Pays: England
ID NLM: 0243704
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
04
12
2019
revised:
24
02
2020
accepted:
24
02
2020
pubmed:
12
3
2020
medline:
30
1
2021
entrez:
12
3
2020
Statut:
ppublish
Résumé
Integrins are the major family of cell adhesion receptors in humans and essential for a wide range of normal physiology, including formation and maintenance of tissue structure integrity, cell migration, proliferation, and differentiation. Integrins also play a prominent role in tumor growth and metastasis. Translational research has tried to define the contribution of integrins to the phenotypic aggressiveness of melanoma because such knowledge is clinically useful. For example, differential expression of integrins in primary cutaneous melanoma can be used to distinguish indolent from aggressive, prometastatic melanoma. Recent studies have shown that gene expression-based testing of patient-derived melanoma tissue is feasible, and molecular tests may fully replace interventional surgical methods such as sentinel lymph node biopsies in the future. Because of their central role in mediating invasion and metastasis, integrins are likely to be useful biomarkers. Integrins are also attractive candidate targets for interventional therapy. This article focuses on the role of integrins in melanoma and highlights recent advances in the field of translational research.
Identifiants
pubmed: 32157692
doi: 10.1111/ijd.14850
pmc: PMC7167356
mid: NIHMS1573713
doi:
Substances chimiques
Biomarkers, Tumor
0
Integrins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
525-534Subventions
Organisme : NCI NIH HHS
ID : K08 CA215105
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000135
Pays : United States
Organisme : NCI NIH HHS
ID : CA215105
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1TR000135
Pays : United States
Informations de copyright
© 2020 the International Society of Dermatology.
Références
Melanoma Res. 2017 Jun;27(3):180-188
pubmed: 28234767
Matrix Biol. 2005 Sep;24(6):418-27
pubmed: 16005200
Curr Biol. 2008 May 20;18(10):R402-R404
pubmed: 18492464
J Invest Dermatol. 1993 May;100(5):640-7
pubmed: 8491987
Nat Rev Cancer. 2010 Jan;10(1):9-22
pubmed: 20029421
Lancet Oncol. 2014 Sep;15(10):1100-8
pubmed: 25163906
Cancer Res. 1990 Oct 15;50(20):6757-64
pubmed: 2208139
Cell Growth Differ. 1999 Jul;10(7):479-90
pubmed: 10437916
Theranostics. 2016 Jan 01;6(1):78-92
pubmed: 26722375
Cancers (Basel). 2017 Aug 23;9(9):
pubmed: 28832494
Drugs Context. 2012 Nov 19;2012:212242
pubmed: 24432031
Cancers (Basel). 2019 Jul 12;11(7):
pubmed: 31336983
J Clin Invest. 1992 Jun;89(6):2018-22
pubmed: 1376331
Int J Cancer. 1993 Apr 22;54(1):68-72
pubmed: 8478149
Melanoma Res. 2004 Feb;14(1):29-37
pubmed: 15091191
Mol Biol Cell. 2001 Sep;12(9):2699-710
pubmed: 11553709
Int J Mol Sci. 2018 Oct 04;19(10):
pubmed: 30287763
J Exp Clin Cancer Res. 2000 Mar;19(1):21-34
pubmed: 10840932
Int J Cancer. 1993 May 8;54(2):315-21
pubmed: 8387465
J Invest Dermatol. 2000 Sep;115(3):337-44
pubmed: 10951266
Cancer Res. 2000 Dec 15;60(24):6805-10
pubmed: 11156369
Cancer Invest. 1997;15(4):318-20
pubmed: 9246152
Structure. 2017 Nov 7;25(11):1732-1739.e5
pubmed: 29033288
Am J Pathol. 2014 Mar;184(3):842-58
pubmed: 24412090
J Exp Clin Cancer Res. 2018 Apr 27;37(1):92
pubmed: 29703238
Clin Cancer Res. 2015 Jan 1;21(1):175-83
pubmed: 25564571
Mol Cancer Ther. 2002 Dec;1(14):1255-64
pubmed: 12516958
Acta Oncol. 1999;38(5):535-47
pubmed: 10427941
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6037-42
pubmed: 9600913
Melanoma Res. 1993 Dec;3(6):435-41
pubmed: 7512849
PLoS One. 2012;7(7):e41591
pubmed: 22848537
J Environ Pathol Toxicol Oncol. 2003;22(3):167-78
pubmed: 14529092
Matrix Biol. 2011 Apr;30(3):207-17
pubmed: 21414405
J Exp Med. 2017 Jun 5;214(6):1679-1690
pubmed: 28473400
Histopathology. 1994 Mar;24(3):249-56
pubmed: 7515372
Hum Pathol. 1999 May;30(5):562-7
pubmed: 10333228
Clin Cancer Res. 2016 Jul 1;22(13):3192-200
pubmed: 26839144
Nature. 2015 Nov 19;527(7578):329-35
pubmed: 26524530
Cancers (Basel). 2017 Jul 26;9(8):
pubmed: 28933725
Annu Rev Med. 2012;63:199-215
pubmed: 22053740
Nat Rev Cancer. 2018 Sep;18(9):533-548
pubmed: 30002479
N Engl J Med. 2017 Nov 9;377(19):1813-1823
pubmed: 28891408
Nature. 2005 Dec 8;438(7069):820-7
pubmed: 16341007
Nat Rev Cancer. 2008 Aug;8(8):604-17
pubmed: 18497750
Melanoma Manag. 2019 Dec 17;6(4):MMT32
pubmed: 31871621
J Nucl Med. 2016 Mar;57(3):460-6
pubmed: 26635338
Int J Biol Macromol. 2016 Jul;88:457-64
pubmed: 27060015
Anticancer Res. 1996 Jul-Aug;16(4B):2321-4
pubmed: 8694563
Eur J Med Chem. 2014 Feb 12;73:225-32
pubmed: 24412498
Cold Spring Harb Perspect Biol. 2011 Mar 01;3(3):
pubmed: 21421922
Cell. 2002 Sep 20;110(6):673-87
pubmed: 12297042
Cell Regul. 1991 Oct;2(10):805-17
pubmed: 1839357
Pharmacol Ther. 1999 Oct;84(1):1-111
pubmed: 10580832
Oncol Rep. 2015 Jun;33(6):2737-45
pubmed: 25872534
J Am Acad Dermatol. 2019 Jun;80(6):e161-e162
pubmed: 30586612
Biochim Biophys Acta Rev Cancer. 2018 Apr;1869(2):321-332
pubmed: 29673969
Mol Ther. 2017 Feb 1;25(2):534-546
pubmed: 28153100
Oncol Res. 2011;19(7):335-48
pubmed: 21936403
Cancers (Basel). 2017 Sep 04;9(9):
pubmed: 28869579
Asia Pac J Clin Oncol. 2010 Mar;6(1):42-8
pubmed: 20398037
J Thromb Haemost. 2018 Sep;16(9):1843-1856
pubmed: 29953749
Nat Med. 2019 Feb;25(2):312-322
pubmed: 30643287
Am J Pathol. 1998 Nov;153(5):1435-42
pubmed: 9811334
Science. 2009 May 15;324(5929):895-9
pubmed: 19443776
Am J Physiol. 1998 Dec;275(6):C1630-9
pubmed: 9843725
Cell. 2015 Sep 24;163(1):160-73
pubmed: 26406376
J Clin Oncol. 2015 Aug 10;33(23):2509-15
pubmed: 26150443
Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8856-60
pubmed: 7522323
Nat Rev Mol Cell Biol. 2014 Apr;15(4):273-88
pubmed: 24651544
Int J Mol Med. 2017 Jun;39(6):1327-1337
pubmed: 28440483
J Cancer Res Clin Oncol. 2013 Feb;139(2):249-58
pubmed: 23052696
Oncotarget. 2018 Apr 17;9(29):20826-20837
pubmed: 29755693
J Natl Cancer Inst. 2018 Jul 1;110(7):777-786
pubmed: 29267866
Science. 1995 Dec 1;270(5241):1500-2
pubmed: 7491498
Gynecol Oncol. 2011 May 1;121(2):273-9
pubmed: 21276608
Ann Oncol. 2013 Jan;24(1):90-6
pubmed: 22904239
Cell. 2007 Jan 12;128(1):171-82
pubmed: 17218263
Cancer. 2010 Mar 15;116(6):1526-34
pubmed: 20108344
Mayo Clin Proc. 2016 Aug;91(8):1147-8
pubmed: 27492918
Science. 2006 May 26;312(5777):1168-71
pubmed: 16728630
Cancer. 1990 Jun 1;65(11):2478-81
pubmed: 1970948
Cancer. 1999 Jan 15;85(2):375-82
pubmed: 10023705