Fibroin nanoparticles: a promising drug delivery system.


Journal

Drug delivery
ISSN: 1521-0464
Titre abrégé: Drug Deliv
Pays: England
ID NLM: 9417471

Informations de publication

Date de publication:
Dec 2020
Historique:
entrez: 12 3 2020
pubmed: 12 3 2020
medline: 1 12 2020
Statut: ppublish

Résumé

Fibroin is a dominant silk protein that possesses ideal properties as a biomaterial for drug delivery. Recently, the development of fibroin nanoparticles (FNPs) for various biomedical applications has been extensively studied. Due to their versatility and chemical modifiability, FNPs can encapsulate different types of therapeutic compounds, including small and big molecules, proteins, enzymes, vaccines, and genetic materials. Moreover, FNPs are able to be administered both parenterally and non-parenterally. This review summaries basic information on the silk and fibroin origin and characteristics, followed by the up-to-date data on the FNPs preparation and characterization methods. In addition, their medical applications as a drug delivery system are in-depth explored based on several administrative routes of parenteral, oral, transdermal, ocular, orthopedic, and respiratory. Finally, the challenges and suggested solutions, as well as the future outlooks of these systems are discussed.

Identifiants

pubmed: 32157919
doi: 10.1080/10717544.2020.1736208
pmc: PMC7144220
doi:

Substances chimiques

Biocompatible Materials 0
Silk 0
Fibroins 9007-76-5

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

431-448

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Auteurs

Duy Toan Pham (DT)

Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.

Waree Tiyaboonchai (W)

Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Mahidol University, Salaya, Thailand.

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