Cognitive behavioral therapy may have a rehabilitative, not normalizing, effect on functional connectivity in adolescent depression.
Adolescent depression
CBT
Cortical thickness
MRI
Resting-state functional connectivity
White matter volume
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 05 2020
01 05 2020
Historique:
received:
23
08
2019
revised:
05
12
2019
accepted:
20
01
2020
pubmed:
12
3
2020
medline:
16
2
2021
entrez:
12
3
2020
Statut:
ppublish
Résumé
Whether the differences in brain structure and function, characteristic of adult major depressive disorder (MDD 128 adolescent MDD patients and 40 adolescent controls were enrolled in the study. We investigated pre-treatment differences in cortical thickness, white matter volume, and resting-state functional connectivity. We also investigated the longitudinal effects of CBT on resting-state functional connectivity, and the relationship between pre-treatment functional disruption and CBT-related changes to resting-state functional connectivity was assessed by the correlation of pre-treatment cross-sectional effects and longitudinal CBT-related effects across multiple brain regions. Patients had greater cortical thickness and white matter volume within fronto-limbic regions of the brain. Patients had greater pre-treatment resting-state functional connectivity within the default-mode, fronto-limbic, central-executive, and salience networks. CBT increased resting-state functional connectivity of the subgenual anterior cingulate and amygdala seeds with predominantly frontal regions. Regions showing the greatest pre-treatment functional disruption showed the weakest CBT-related changes. For ethical reasons, there was no placebo group. Adolescent MDD is associated with structural and functional differences also seen in adult patients. CBT-related changes in resting-state functional connectivity do not appear to show a normalizing effect, but instead indicate rehabilitative effects on resting-state functional connectivity.
Sections du résumé
BACKGROUND
Whether the differences in brain structure and function, characteristic of adult major depressive disorder (MDD
METHODS
128 adolescent MDD patients and 40 adolescent controls were enrolled in the study. We investigated pre-treatment differences in cortical thickness, white matter volume, and resting-state functional connectivity. We also investigated the longitudinal effects of CBT on resting-state functional connectivity, and the relationship between pre-treatment functional disruption and CBT-related changes to resting-state functional connectivity was assessed by the correlation of pre-treatment cross-sectional effects and longitudinal CBT-related effects across multiple brain regions.
RESULTS
Patients had greater cortical thickness and white matter volume within fronto-limbic regions of the brain. Patients had greater pre-treatment resting-state functional connectivity within the default-mode, fronto-limbic, central-executive, and salience networks. CBT increased resting-state functional connectivity of the subgenual anterior cingulate and amygdala seeds with predominantly frontal regions. Regions showing the greatest pre-treatment functional disruption showed the weakest CBT-related changes.
LIMITATIONS
For ethical reasons, there was no placebo group.
CONCLUSIONS
Adolescent MDD is associated with structural and functional differences also seen in adult patients. CBT-related changes in resting-state functional connectivity do not appear to show a normalizing effect, but instead indicate rehabilitative effects on resting-state functional connectivity.
Identifiants
pubmed: 32157998
pii: S0165-0327(19)32251-7
doi: 10.1016/j.jad.2020.01.103
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-11Subventions
Organisme : Medical Research Council
ID : G0802226
Pays : United Kingdom
Organisme : Department of Health
ID : 06-05-01
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 095844/Z/11/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Luca Villa, Professor Suckling, Dr. Wilkinson, Dr. Tait, and Professor Reynolds have no conflicts of interest to disclose. Professor Ian Goodyer has received consulting fees from Lundbeck Pharmaceuticals and is supported by a strategic award from the Wellcome Trust (095844/Z/11/Z). Dr. Raphael Kelvin has received consulting fees from Lundbeck Pharmaceuticals.