A Prospective Observational Multi-institutional Study on Invasive Fungal Infections Following Chemotherapy for Acute Myeloid Leukemia (MISFIC Study): A Real World Scenario from India.
AML
Fungal infection
Incidence
India
Journal
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
ISSN: 0971-4502
Titre abrégé: Indian J Hematol Blood Transfus
Pays: India
ID NLM: 9425818
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
18
07
2019
accepted:
13
08
2019
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
12
3
2020
Statut:
ppublish
Résumé
We performed a prospective multi-centre observational study to understand the incidence of IFI in patients with AML in India with use of anti-fungal prophylaxis. All patients with AML receiving either induction chemotherapy or salvage chemotherapy between November 2014 and February 2016 were included in this prospective observational study from 10 Indian centres. IFI was defined as per the revised EORTC-MSG criteria. Data on type of chemotherapy used, type of anti-fungal prophylaxis used, time to neutrophil recovery, incidence of IFI and survival were collected. Two hundred patients (118 male and 82 females) with a median age of 35 years (range: 2-66) were recruited. One hundred and eighty-six (93%) had newly diagnosed acute myeloid leukemia (AML) while 14 (7%) had relapsed disease. IFI occurred in 53 patients (26.5%) with proven or probable IFI occurring in 17 (8.5%). Use of posaconazole prophylaxis (
Identifiants
pubmed: 32158091
doi: 10.1007/s12288-019-01173-y
pii: 1173
pmc: PMC7042421
doi:
Types de publication
Journal Article
Langues
eng
Pagination
97-103Informations de copyright
© Indian Society of Hematology and Blood Transfusion 2019.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare that they have no conflicts of interest.
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