"Inflammaging" and bone in the OsteoLaus cohort.
Bone mineral density
Cytokines
Inflammation
Osteoporosis
Trabecular bone score
Journal
Immunity & ageing : I & A
ISSN: 1742-4933
Titre abrégé: Immun Ageing
Pays: England
ID NLM: 101235427
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
12
2019
accepted:
27
02
2020
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
12
3
2020
Statut:
epublish
Résumé
"Inflammaging" is a coined term that combines the processes of inflammation (within the normal range) and aging, since chronic, low-grade, systemic inflammation emerges with increasing age. Unlike high-level inflammation, with which deleterious effects on bone no longer need to be demonstrated, it is unclear whether inflammaging exerts deleterious effects on bone too. We assessed associations between inflammaging - measured via cytokine levels (high-sensitivity C-reactive protein (hs-CRP); interleukin- Mean (±SD) age was 64.5 ± 7.6 and mean bone mass index (BMI) 25.9 ± 4.5 kg/m2. Median hs-CRP, IL- Our results suggest that bone imaging and structure parameters are not associated with the low-grade cytokine levels (within the normal range) observed with inflammaging.
Sections du résumé
BACKGROUND
BACKGROUND
"Inflammaging" is a coined term that combines the processes of inflammation (within the normal range) and aging, since chronic, low-grade, systemic inflammation emerges with increasing age. Unlike high-level inflammation, with which deleterious effects on bone no longer need to be demonstrated, it is unclear whether inflammaging exerts deleterious effects on bone too.
METHOD
METHODS
We assessed associations between inflammaging - measured via cytokine levels (high-sensitivity C-reactive protein (hs-CRP); interleukin-
RESULTS
RESULTS
Mean (±SD) age was 64.5 ± 7.6 and mean bone mass index (BMI) 25.9 ± 4.5 kg/m2. Median hs-CRP, IL-
CONCLUSION
CONCLUSIONS
Our results suggest that bone imaging and structure parameters are not associated with the low-grade cytokine levels (within the normal range) observed with inflammaging.
Identifiants
pubmed: 32158491
doi: 10.1186/s12979-020-00177-x
pii: 177
pmc: PMC7057650
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsDidier Hans holds stock in the Medimaps Group, makers of trabecular bone score software. Bérengère Aubry-Rozier, Jessica Fischer, Pedro Marques-Vidal, Peter Vollenweider and Olivier Lamy state that they have no conflicts of interest.
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