Detection of immunoglobulin G levels produced by oral polio vaccine in HIV infected children in Jos, Plateau State, Nigeria.
Immunoglobulin G
human immunodeficiency virus
oral polio vaccine
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2019
2019
Historique:
received:
26
07
2018
accepted:
24
09
2019
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
18
3
2020
Statut:
epublish
Résumé
Disease eradication requires a long time and efficient management as compared to disease control program. After successful small pox eradication, polio virus causing poliomyelitis is choice for next eradication. The corner stone of the global polio eradication initiative is the immunization of children with multiple doses of Oral Polio Vaccine (OPV) through both Routine Immunization (RI) and Supplemental Immunization Activities (SIAs). This informed our design of this prospective study. Objective is to determine levels of Immunoglobulin G antibodies produced in HIV infected children aged (one to ten years) vaccinated with Oral Polio Vaccine (OPV) in Jos, Plateau State, Nigeria. One hundred and eighty-two children infected with HIV who had received Oral Polio Vaccine (OPV) at least four times had their blood samples collected and assayed for the presence of Polio Specific IgG antibodies using IgG ELISA test kit (DEMEDITEC Diagnostic GmbH, Germany). Three millilitre (3ml) of venous blood samples were collected aseptically by venepuncture. Sera obtained were assayed using Enzyme immunoassay detection and quantitative determination of human IgG antibodies against poliomyelitis virus in serum and plasma (Demeditic Poliomyelitis Virus IgG ELISA DEPOL01-Germany). The result showed that 95.6% (174/182) of the tested children had detectable IgG antibodies against polio virus. The high proportion of 95.6% recorded in this study indicates HIV infected children responded effectively to the Oral Polio Vaccine (OPV) being used in the ongoing polio eradication initiative. In this study, 4.4% (8/182) of the HIV infected children were not producing detectable amount of antibodies that could protect them from exposure to wild type of polio virus. This study shows that HIV infected children had detectable antibodies (Immunoglobulin G) against polio virus. Despite the overall progress recorded in the fight against poliomyelitis in Nigeria, a lot needs to be done to further strengthen the fight against poliomyelitis in Nigeria.
Identifiants
pubmed: 32158512
doi: 10.11604/pamj.2019.34.183.16665
pii: PAMJ-34-183
pmc: PMC7049312
doi:
Substances chimiques
Immunoglobulin G
0
Poliovirus Vaccine, Oral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
183Informations de copyright
© Fwangshak Ayuba Lengkat et al.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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