The effects of pentoxifylline and tocopherol in jaw osteomyelitis.
Osteomyelitis
Panoramic radiography
Pentoxifylline
Tocopherols
Journal
Journal of the Korean Association of Oral and Maxillofacial Surgeons
ISSN: 2234-7550
Titre abrégé: J Korean Assoc Oral Maxillofac Surg
Pays: Korea (South)
ID NLM: 101580242
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
29
09
2018
revised:
09
10
2018
accepted:
09
10
2018
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
12
3
2020
Statut:
ppublish
Résumé
Pentoxifylline (PTX) is a methylxanthine derivative that has been implicated in the pathogenesis of peripheral vessel disease and intermittent lameness. The purpose of this study was to investigate the effect of PTX and tocopherol in patients diagnosed with osteoradionecrosis (ORN), bisphosphonate-related osteonecrosis of the jaw (BRONJ), and chronic osteomyelitis using digital panoramic radiographs. This study was performed in 25 patients who were prescribed PTX and tocopherol for treatment of ORN, BRONJ, and chronic osteomyelitis between January 2014 and May 2018 in Seoul National University Dental Hospital. Radiographic densities of the dental panorama were compared prior to starting PTX and tocopherol, at 3 months, and at 6 months after prescription. Radiographic densities were measured using Adobe Photoshop CS6 (Adobe System Inc., USA). Blood sample tests showing the degree of inflammation at the initial visit were considered the baseline and compared with results after 3 to 6 months. Statistical analysis was performed using the Mann-Whitney test and repeated measurement ANOVA using IBM SPSS 23.0 (IBM Corp., USA). Eight patients were diagnosed with ORN, nine patients with BRONJ, and the other 8 patients with chronic osteomyelitis. Ten of the 25 patients were men, average age was 66.32±14.39 years, and average duration of medication was 151.8±80.65 days (range, 56-315 days). Statistically significant increases were observed in the changes between 3 and 6 months after prescription ( Long-term use of PTX and tocopherol can be an auxiliary method in the treatment of ORN, BRONJ, or chronic osteomyelitis in jaw.
Identifiants
pubmed: 32158677
doi: 10.5125/jkaoms.2020.46.1.19
pmc: PMC7049758
doi:
Types de publication
Journal Article
Langues
eng
Pagination
19-27Informations de copyright
Copyright © 2020 The Korean Association of Oral and Maxillofacial Surgeons.
Déclaration de conflit d'intérêts
Conflict of Interest: No potential conflict of interest relevant to this article was reported.
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