Radiation Induced Demyelination in Cervical Spinal Cord of the Head and Neck Cancer Patients after Receiving Radiotherapy.
Demyelination
Magnetic Resonance Imaging
Myelin
Radiotherapy
Spinal Cord
Journal
Journal of biomedical physics & engineering
ISSN: 2251-7200
Titre abrégé: J Biomed Phys Eng
Pays: Iran
ID NLM: 101589641
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
30
11
2018
accepted:
27
12
2018
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
12
3
2020
Statut:
epublish
Résumé
Cervical spinal cord is important and radiosensitive. It is the most critical organ for the head and neck (H&N) cancer patients during radiotherapy. If the delivered dose to the cord is more than tolerance dose, demyelination may occur. Current study aims to analyze the post radiotherapy status of cord in the H&N cancer patients. In this analytical study, sixty patients who received more than 50 Gray (Gy) dose for more than 10 cm length of spinal cord participated in the study. All the patients were clinically examined and magnetic resonance imaging (MRI) was performed for patients who had demyelination symptoms. Adequate medical management was provided for all the patients having demyelination. Out of sixty patients, ten cases were reported with demyelination symptoms, and only six cases gave consent for this study. One patient was found to have irreversible demyelination while five patients had reversible demyelination. Demyelination may occur if long segment spinal cord receives dose more than tolerance limit. However target dose should not be compromised up to 54 Gy to spinal cord.
Sections du résumé
BACKGROUND
BACKGROUND
Cervical spinal cord is important and radiosensitive. It is the most critical organ for the head and neck (H&N) cancer patients during radiotherapy. If the delivered dose to the cord is more than tolerance dose, demyelination may occur.
OBJECTIVE
OBJECTIVE
Current study aims to analyze the post radiotherapy status of cord in the H&N cancer patients.
MATERIAL AND METHODS
METHODS
In this analytical study, sixty patients who received more than 50 Gray (Gy) dose for more than 10 cm length of spinal cord participated in the study. All the patients were clinically examined and magnetic resonance imaging (MRI) was performed for patients who had demyelination symptoms. Adequate medical management was provided for all the patients having demyelination.
RESULTS
RESULTS
Out of sixty patients, ten cases were reported with demyelination symptoms, and only six cases gave consent for this study. One patient was found to have irreversible demyelination while five patients had reversible demyelination.
CONCLUSION
CONCLUSIONS
Demyelination may occur if long segment spinal cord receives dose more than tolerance limit. However target dose should not be compromised up to 54 Gy to spinal cord.
Identifiants
pubmed: 32158706
doi: 10.31661/jbpe.v0i0.1055
pii: JBPE-10-1
pmc: PMC7036413
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1-6Informations de copyright
Copyright: © 2020: Journal of Biomedical Physics and Engineering.
Déclaration de conflit d'intérêts
Conflict of Interest: None
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