Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI.
Contrast media
Gadolinium
Magnetic Resonance Imaging
Journal
Journal of biomedical physics & engineering
ISSN: 2251-7200
Titre abrégé: J Biomed Phys Eng
Pays: Iran
ID NLM: 101589641
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
17
09
2018
accepted:
12
10
2018
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
12
3
2020
Statut:
epublish
Résumé
Glucose transporter (Glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas. In this study, we evaluated a magnetic resonance (MR) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (Gd In this experimental study, 3T magnetic resonance imaging (MRI) scanner was used to assess the specific interactions between Glut1-overexpressing tumor cells (MDA-MB-231) and Gd It was found that the acquired MRI T Results have shown that glucose-shell of magnetic nanoparticles has a key role in diagnosing cancer cells of high metabolic activity.
Sections du résumé
BACKGROUND
BACKGROUND
Glucose transporter (Glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas.
OBJECTIVE
OBJECTIVE
In this study, we evaluated a magnetic resonance (MR) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (Gd
MATERIAL AND METHODS
METHODS
In this experimental study, 3T magnetic resonance imaging (MRI) scanner was used to assess the specific interactions between Glut1-overexpressing tumor cells (MDA-MB-231) and Gd
RESULTS
RESULTS
It was found that the acquired MRI T
CONCLUSION
CONCLUSIONS
Results have shown that glucose-shell of magnetic nanoparticles has a key role in diagnosing cancer cells of high metabolic activity.
Identifiants
pubmed: 32158709
doi: 10.31661/jbpe.v0i0.1018
pii: JBPE-10-1
pmc: PMC7036409
doi:
Types de publication
Journal Article
Langues
eng
Pagination
25-38Informations de copyright
Copyright: © 2020: Journal of Biomedical Physics and Engineering.
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