Transcranial Focused Ultrasound Modulates Electrical Behavior of the Neurons: Design and Implementation of a Model.
Acoustic Stimulation
Action Potentials
Low Intensity Pulsed Ultrasound
Ultrasonic Wave
Journal
Journal of biomedical physics & engineering
ISSN: 2251-7200
Titre abrégé: J Biomed Phys Eng
Pays: Iran
ID NLM: 101589641
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
22
11
2018
accepted:
15
12
2018
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
12
3
2020
Statut:
epublish
Résumé
Recently, ultrasonic neuromodulation research has been an important and interesting issue. Ultrasonic neuromodulation is possible by the use of low-intensity transcranial focused ultrasound (tFUS) to stimulate or inhibit the neural structures. The primary capability of this method is the improvement in the treatment progress of certain neurological and psychiatric disorders noninvasively. tFUS is able to modulate ionic currents and neural depolarization, causing the alteration in electrical properties of neurons. The study aims to investigate the effect of tFUS waves on the electrical behavior of neurons using the simulation method. In the first part of this simulation study, the propagation of tFUS waves throughout the head was simulated to calculate the value of acoustic pressure at the cortex. In the second part, cortical neurons were simulated by a simple model of spiking neurons proposed by Izhikevich for three common dynamics. Then, the capacitance model was proposed to determine the alteration in the electrical behavior of the neurons during tFUS stimulation. At the resting state, the electric potential of the neuron's membrane through the tFUS stimulation has an amplitude of about 30 mv with the similar oscillatory behavior of the acoustic waveform; while,the ultimate electrical behavior of the neuron's membrane indicates a decrease in the electric potential when the neurons fire. The electrical behavior of the neuron and the range of its membrane voltage modulated during ultrasonic stimulation. The reduction in the amplitude of membrane potential was observed while neuron spikes.
Sections du résumé
BACKGROUND
BACKGROUND
Recently, ultrasonic neuromodulation research has been an important and interesting issue. Ultrasonic neuromodulation is possible by the use of low-intensity transcranial focused ultrasound (tFUS) to stimulate or inhibit the neural structures. The primary capability of this method is the improvement in the treatment progress of certain neurological and psychiatric disorders noninvasively. tFUS is able to modulate ionic currents and neural depolarization, causing the alteration in electrical properties of neurons.
OBJECTIVE
OBJECTIVE
The study aims to investigate the effect of tFUS waves on the electrical behavior of neurons using the simulation method.
MATERIAL AND METHODS
METHODS
In the first part of this simulation study, the propagation of tFUS waves throughout the head was simulated to calculate the value of acoustic pressure at the cortex. In the second part, cortical neurons were simulated by a simple model of spiking neurons proposed by Izhikevich for three common dynamics. Then, the capacitance model was proposed to determine the alteration in the electrical behavior of the neurons during tFUS stimulation.
RESULTS
RESULTS
At the resting state, the electric potential of the neuron's membrane through the tFUS stimulation has an amplitude of about 30 mv with the similar oscillatory behavior of the acoustic waveform; while,the ultimate electrical behavior of the neuron's membrane indicates a decrease in the electric potential when the neurons fire.
CONCLUSION
CONCLUSIONS
The electrical behavior of the neuron and the range of its membrane voltage modulated during ultrasonic stimulation. The reduction in the amplitude of membrane potential was observed while neuron spikes.
Identifiants
pubmed: 32158713
doi: 10.31661/jbpe.v0i0.1052
pii: JBPE-10-1
pmc: PMC7036408
doi:
Types de publication
Journal Article
Langues
eng
Pagination
65-74Informations de copyright
Copyright: © 2020: Journal of Biomedical Physics and Engineering.
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