Attenuation of the Hepatoprotective Effects of Ileal Apical Sodium Dependent Bile Acid Transporter (ASBT) Inhibition in Choline-Deficient L-Amino Acid-Defined (CDAA) Diet-Fed Mice.
cholesterol
fat absorption
fibrosis
liver
triglyceride
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
11
2019
accepted:
10
02
2020
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
12
3
2020
Statut:
epublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) is a major growing worldwide health problem. We previously reported that interruption of the enterohepatic circulation of bile acids using a non-absorbable apical sodium-dependent bile acid transporter inhibitor (ASBTi; SC-435) reduced the development of NAFLD in high fat diet fed mice. However, the ability of ASBTi treatment to impact the progression of NAFLD to non-alcoholic steatohepatitis (NASH) and fibrosis in a diet-induced mouse model remains untested. In the current study, we assessed whether ASBTi treatment is hepatoprotective in the choline-deficient, L-amino acid-defined (CDAA) diet model of NASH-induced fibrosis.
Identifiants
pubmed: 32158763
doi: 10.3389/fmed.2020.00060
pmc: PMC7052288
doi:
Types de publication
Journal Article
Langues
eng
Pagination
60Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK047987
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK056239
Pays : United States
Organisme : NIDDK NIH HHS
ID : R29 DK047987
Pays : United States
Informations de copyright
Copyright © 2020 Rao, Peppel, Gumber, Karpen and Dawson.
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