Eating Pattern Response to a Low-Fat Diet Intervention and Cardiovascular Outcomes in Normotensive Women: The Women's Health Initiative.
cardiovascular outcomes
food choices
low-fat diet
normotensive women
self-selected dietary change
vegetable protein
Journal
Current developments in nutrition
ISSN: 2475-2991
Titre abrégé: Curr Dev Nutr
Pays: United States
ID NLM: 101717957
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
08
01
2020
revised:
04
02
2020
accepted:
06
02
2020
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
12
3
2020
Statut:
epublish
Résumé
Women without cardiovascular disease (CVD) or hypertension at baseline assigned to intervention in the Women's Health Initiative Dietary Modification (DM) trial experienced 30% lower risk of coronary heart disease (CHD), whereas results in women with hypertension or prior CVD could have been confounded by postrandomization use of statins. Intervention participants reported various self-selected changes to achieve the 20% total fat goals. Reviewed are intervention compared with comparison group HRs for CHD, stroke, and total CVD in relation to specific dietary changes in normotensive participants. Dietary change was assessed by comparing baseline with year 1 FFQ data in women ( Intervention participants self-reported compensating reduced energy intake from total fat by increasing carbohydrate and protein. Specifically they increased plant protein, with those in the upper quartile (increased total protein by ≥3.3% of energy) having a CHD HR of 0.39 (95% CI: 0.22, 0.71), compared with 0.92 (95% CI: 0.57, 1.48) for those in the lower quartile of change (decreased total protein ≥0.6% of energy), with Intervention group total fat reduction replaced with increased carbohydrate and some protein, especially plant-based protein, was related to lower CHD risk in normotensive women without CVD who reported high baseline total fat intake. This trial was registered at clinicaltrials.gov as NCT00000611. Link to the WHI trial protocol: https://www.whi.org/about/SitePages/Dietary%20Trial.aspx.
Sections du résumé
BACKGROUND
BACKGROUND
Women without cardiovascular disease (CVD) or hypertension at baseline assigned to intervention in the Women's Health Initiative Dietary Modification (DM) trial experienced 30% lower risk of coronary heart disease (CHD), whereas results in women with hypertension or prior CVD could have been confounded by postrandomization use of statins.
OBJECTIVES
OBJECTIVE
Intervention participants reported various self-selected changes to achieve the 20% total fat goals. Reviewed are intervention compared with comparison group HRs for CHD, stroke, and total CVD in relation to specific dietary changes in normotensive participants.
METHODS
METHODS
Dietary change was assessed by comparing baseline with year 1 FFQ data in women (
RESULTS
RESULTS
Intervention participants self-reported compensating reduced energy intake from total fat by increasing carbohydrate and protein. Specifically they increased plant protein, with those in the upper quartile (increased total protein by ≥3.3% of energy) having a CHD HR of 0.39 (95% CI: 0.22, 0.71), compared with 0.92 (95% CI: 0.57, 1.48) for those in the lower quartile of change (decreased total protein ≥0.6% of energy), with
CONCLUSIONS
CONCLUSIONS
Intervention group total fat reduction replaced with increased carbohydrate and some protein, especially plant-based protein, was related to lower CHD risk in normotensive women without CVD who reported high baseline total fat intake. This trial was registered at clinicaltrials.gov as NCT00000611. Link to the WHI trial protocol: https://www.whi.org/about/SitePages/Dietary%20Trial.aspx.
Identifiants
pubmed: 32159070
doi: 10.1093/cdn/nzaa021
pii: nzaa021
pmc: PMC7056819
doi:
Banques de données
ClinicalTrials.gov
['NCT00000611']
Types de publication
Journal Article
Langues
eng
Pagination
nzaa021Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK111022
Pays : United States
Organisme : NIDDK NIH HHS
ID : P60 DK020541
Pays : United States
Informations de copyright
Copyright © The Author(s) 2020.
Références
Ann Epidemiol. 1999 Apr;9(3):178-87
pubmed: 10192650
Am J Clin Nutr. 2001 Jul;74(1):80-9
pubmed: 11451721
JAMA. 2014 Dec 17;312(23):2531-41
pubmed: 25514303
J Acad Nutr Diet. 2013 Apr;113(4):569-80
pubmed: 23415502
JAMA. 2006 Feb 8;295(6):655-66
pubmed: 16467234
N Engl J Med. 2001 Jan 4;344(1):3-10
pubmed: 11136953
J Am Diet Assoc. 2008 Nov;108(11):1896-901
pubmed: 18954580
J Hypertens. 2003 Jun;21(6):1055-76
pubmed: 12777939
Am J Epidemiol. 2008 May 15;167(10):1247-59
pubmed: 18344516
N Engl J Med. 2003 Jun 26;348(26):2599-608
pubmed: 12826634
Arch Intern Med. 2008 Apr 14;168(7):713-20
pubmed: 18413553
J Am Diet Assoc. 2004 Apr;104(4):654-8
pubmed: 15054353
JAMA. 2006 Feb 8;295(6):643-54
pubmed: 16467233
J Clin Oncol. 2017 Sep 1;35(25):2919-2926
pubmed: 28654363
J Nutr. 2012 Jun;142(6):1009-18
pubmed: 22513989
Curr Atheroscler Rep. 2013 May;15(5):324
pubmed: 23512608
Control Clin Trials. 1998 Feb;19(1):61-109
pubmed: 9492970
J Am Diet Assoc. 2003 Apr;103(4):454-60
pubmed: 12669007
Ann Epidemiol. 1995 Mar;5(2):108-18
pubmed: 7795829
J Am Coll Cardiol. 2014 Jul 1;63(25 Pt B):2960-84
pubmed: 24239922
J Nutr. 2018 May 1;148(5):771-780
pubmed: 29897561
Crit Rev Food Sci Nutr. 2018 May 24;58(8):1260-1270
pubmed: 28605204
Am J Clin Nutr. 2017 Jul;106(1):35-43
pubmed: 28515068
JAMA. 2006 Feb 8;295(6):629-42
pubmed: 16467232
Am J Epidemiol. 1986 Sep;124(3):453-69
pubmed: 3740045
N Engl J Med. 2013 Apr 4;368(14):1353-4
pubmed: 23550674
N Engl J Med. 1997 Apr 17;336(16):1117-24
pubmed: 9099655
Diabetes Care. 2018 Apr;41(4):680-687
pubmed: 29282203
N Engl J Med. 2018 Jun 21;378(25):e34
pubmed: 29897866
Lancet. 2017 Nov 4;390(10107):2050-2062
pubmed: 28864332
Am J Hypertens. 2016 Aug;29(8):959-68
pubmed: 26708006
Circulation. 2009 Mar 3;119(8):1093-100
pubmed: 19221219
J Am Diet Assoc. 1988 Oct;88(10):1268-71
pubmed: 3171020
JAMA. 2005 Nov 16;294(19):2455-64
pubmed: 16287956
Nutr Metab Cardiovasc Dis. 2007 Mar;17(3):171-4
pubmed: 17320361