Engineering human stellate cells for beta cell replacement therapy promotes
CCL22
Immune engineering
Islet transplantation
Regulatory T cells
Stellate cells
Journal
Materials today. Bio
ISSN: 2590-0064
Titre abrégé: Mater Today Bio
Pays: England
ID NLM: 101757228
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
28
01
2019
revised:
02
05
2019
accepted:
02
05
2019
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
12
3
2020
Statut:
epublish
Résumé
Type 1 diabetes (T1D) is an autoimmune disease characterized by destruction of pancreatic β cells. One of the promising therapeutic approaches in T1D is the transplantation of islets; however, it has serious limitations. To address these limitations, immunotherapeutic strategies have focused on restoring immunologic tolerance, preventing transplanted cell destruction by patients' own immune system. Macrophage-derived chemokines such as chemokine-ligand-22 (CCL22) can be utilized for regulatory T cell (Treg) recruitment and graft tolerance. Stellate cells (SCs) have various immunomodulatory functions: recruitment of Tregs and induction of T-cell apoptosis. Here, we designed a unique immune-privileged microenvironment around implantable islets through overexpression of CCL22 proteins by SCs. We prepared pseudoislets with insulin-secreting mouse insulinoma-6 (MIN6) cells and human SCs as a model to mimic naive islet morphology. Our results demonstrated that transduced SCs can secrete CCL22 and recruit Tregs toward the implantation site
Identifiants
pubmed: 32159143
doi: 10.1016/j.mtbio.2019.100006
pii: S2590-0064(19)30007-9
pii: 100006
pmc: PMC7061575
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100006Informations de copyright
© 2019 The Authors.
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